Steven Y Cheng
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Explore the profile of Steven Y Cheng including associated specialties, affiliations and a list of published articles.
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39
Citations
947
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Recent Articles
1.
Yang X, Wang Q, Li T, Zhou Y, Gao J, Ma W, et al.
J Biol Chem
. 2025 Feb;
301(3):108249.
PMID: 39894222
The Tetralogy of Fallot (TOF), the most prevalent form of cyanotic congenital heart disease, stems from abnormal development of the outflow tract during embryogenesis. Despite the crucial role played by...
2.
Cheng S, Zhang Y
Cell Chem Biol
. 2024 Jul;
31(7):1231-1233.
PMID: 39029450
In this issue of Cell Chemical Biology, Liu et al. report the identification of Q29, a synthetic diterpenoid that blocks covalent cholesterol modification of smoothened (SMO) and inhibits hedgehog signaling....
3.
Han B, Wang Y, Yue S, Zhang Y, Kuang L, Gao B, et al.
JCI Insight
. 2024 Feb;
9(6).
PMID: 38358805
Suppressor of fused (SUFU) is widely regarded as a key negative regulator of the sonic hedgehog (SHH) morphogenic pathway and a known tumor suppressor of medulloblastoma (MB). However, we report...
4.
Yao Y, Li T, Yu T, Yang X, Wang Y, Cai J, et al.
Biochem Cell Biol
. 2023 Feb;
101(4):284-293.
PMID: 36821837
Studies in the past decade have shown that lipid droplets stored in liver cells under starvation are encapsulated by autophagosomes and fused to lysosomes via the endocytic system. Autophagy responds...
5.
Cai J, Wang Y, Wang X, Ai Z, Li T, Pu X, et al.
Cell Biosci
. 2023 Jan;
13(1):15.
PMID: 36683064
Background: Medulloblastoma (MB) is one of the most common malignant pediatric brain tumors. Metastasis and relapse are the leading causes of death in MB patients. The initiation of the SHH...
6.
Cheng S, Lauth M, Liu A
Front Cell Dev Biol
. 2022 Sep;
10:1010230.
PMID: 36120558
No abstract available.
7.
Yang X, Jin N, Wang Y, Yao Y, Wang Y, Li T, et al.
Biochim Biophys Acta Mol Cell Res
. 2021 Aug;
1868(12):119124.
PMID: 34419491
Autophagy is a highly conservative self-digestion process to maintain intracellular homeostasis and to ensure the survival of cells under stress. Activation of Sonic Hedgehog (Shh) signaling depends on the normal...
8.
Zhuang T, Zhang B, Song Y, Huang F, Chi W, Xin G, et al.
Proc Natl Acad Sci U S A
. 2021 Jul;
118(28).
PMID: 34260378
Centrosome duplication and DNA replication are two pivotal events that higher eukaryotic cells use to initiate proliferation. While DNA replication is initiated through origin licensing, centrosome duplication starts with cartwheel...
9.
Han B, Sun Z, Yu T, Wang Y, Kuang L, Li T, et al.
Cell Death Discov
. 2021 May;
7(1):120.
PMID: 34021128
Although E3 ligase Speckle type BTB/POZ protein (SPOP) promotes tumorigenesis by acting as a key regulatory hub in clear cell renal cell carcinoma (ccRCC), the detailed molecular mechanism remains unclear....
10.
Yu T, Xu Q, Li S, Huang H, Dugan S, Shao L, et al.
Cell Biosci
. 2021 Mar;
11(1):47.
PMID: 33653390
Background: Skeletal development and maintenance are complex processes known to be coordinated by multiple genetic and epigenetic signaling pathways. However, the role of long non-coding RNAs (lncRNAs), a class of...