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Steven Wiltshire

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Articles 31
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Recent Articles
11.
Loh A, Wiltshire S, Emery J, Carter K, Palmer L
Bioinformatics . 2008 Mar; 24(9):1210-1. PMID: 18346980
Summary: Traditional two-dimensional (2D) software programs for drawing pedigrees are limited when dealing with extended pedigrees. In successive generations, the number of individuals grows exponentially, leading to an unworkable amount...
12.
Peters K, Wiltshire S, Henders A, Dragovic M, Badcock J, Chandler D, et al.
Am J Med Genet B Neuropsychiatr Genet . 2008 Mar; 147B(7):1159-66. PMID: 18314870
In a previous study we identified a relatively homogeneous subtype of schizophrenia characterized by pervasive cognitive deficit, which was the exclusive contributor to our findings of linkage to 6p25-p24. The...
13.
Wiltshire S, Powell B, Jennens M, McCaskie P, Carter K, Palmer L, et al.
Hum Genet . 2008 Feb; 123(3):307-13. PMID: 18288492
Endothelin-1 is a potent vasoconstrictor in the body. Previous studies have identified associations between the coding polymorphism K198N and hypertension, systolic blood pressure and HDL levels. We sought to examine...
14.
Xiao J, Zhang F, Wiltshire S, Hung J, Jennens M, Beilby J, et al.
Atherosclerosis . 2008 Jan; 199(2):333-9. PMID: 18179799
Serum high density lipoprotein (HDL) levels are inversely related to the development of coronary artery disease (CAD). Apolipoproteins AI and AII are the major protein constituents of HDL particles. APOAI...
15.
Wiltshire S, Morris A, Zeggini E
Genet Epidemiol . 2007 Dec; 32(3):204-14. PMID: 18064636
Interpretation of dense single nucleotide polymorphism (SNP) follow-up of genome-wide association or linkage scan signals can be facilitated by establishing expectation for the behaviour of primary mapping signals upon fine-mapping,...
16.
Gueorguiev M, Wiltshire S, Garcia E, Mein C, Lecoeur C, Kristen B, et al.
J Clin Endocrinol Metab . 2007 Mar; 92(6):2201-4. PMID: 17389697
Context: Recently, a quantitative trait locus for stature was reported on chromosome 3p26 in patients with type 2 diabetes. Objective: Given that ghrelin is a peptide involved in GH release...
17.
Groves C, Zeggini E, Minton J, Frayling T, Weedon M, Rayner N, et al.
Diabetes . 2006 Aug; 55(9):2640-4. PMID: 16936215
Recent data suggest that common variation in the transcription factor 7-like 2 (TCF7L2) gene is associated with type 2 diabetes. Evaluation of such associations in independent samples provides necessary replication...
18.
Wiltshire S, de Bakker P, Daly M
Eur J Hum Genet . 2006 Jun; 14(11):1209-14. PMID: 16804554
Genome-wide association scans are rapidly becoming reality, but there is no present consensus regarding genotyping strategies to optimise the discovery of true genetic risk factors. For a given investment in...
19.
Groves C, Zeggini E, Walker M, Hitman G, Levy J, ORahilly S, et al.
Diabetes . 2006 May; 55(6):1884-9. PMID: 16731858
Obesity is a major health problem, and many family-based studies have suggested that it has a strong genetic basis. We performed a genome-wide quantitative trait linkage scan for loci influencing...
20.
Tzenova Bell J, Wallace C, Dobson R, Wiltshire S, Mein C, Pembroke J, et al.
Hum Mol Genet . 2006 Mar; 15(8):1365-74. PMID: 16543358
It is well established that gene interactions influence common human diseases, but to date linkage studies have been constrained to searching for single genes across the genome. We applied a...