Steven S Rosenfeld
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Explore the profile of Steven S Rosenfeld including associated specialties, affiliations and a list of published articles.
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67
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2216
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Recent Articles
1.
Goldberg A, Dovas A, Torres D, Pereira B, Viswanathan A, Das Sharma S, et al.
Neuron
. 2025 Jan;
PMID: 39837324
Gliomas are aggressive neoplasms that diffusely infiltrate the brain and cause neurological symptoms, including cognitive deficits and seizures. Increased mTOR signaling has been implicated in glioma-induced neuronal hyperexcitability, but the...
2.
Zarco N, Dovas A, de Araujo Farias V, Nagaiah N, Haddock A, Sims P, et al.
iScience
. 2024 Dec;
27(12):111311.
PMID: 39640583
While mitotic spindle inhibitors specifically kill proliferating tumor cells without the toxicities of microtubule poisons, resistance has limited their clinical utility. Treating glioblastomas with the spindle inhibitors ispinesib, alisertib, or...
3.
Zarco N, Dovas A, de Araujo Farias V, Nagaiah N, Haddock A, Sims P, et al.
bioRxiv
. 2024 Jun;
PMID: 38895402
Highlights: • Resistance to non-microtubule spindle inhibitors limits their efficacy in glioblastoma and depends on STAT3.• Resistance goes hand in hand with development of therapy induced senescence (TIS).• Spindle inhibitor...
4.
Kenchappa R, Radnai L, Young E, Zarco N, Lin L, Dovas A, et al.
bioRxiv
. 2024 May;
PMID: 38746089
Highlights: MT-125 is a highly specific small molecule inhibitor of non-muscle myosin IIA and IIB, is well-tolerated, and achieves therapeutic concentrations in the brain with systemic dosing.Treating preclinical models of...
5.
Cheng Y, Banu M, Zhao W, Rosenfeld S, Canoll P, Sims P
Cell Rep
. 2024 Apr;
43(5):114139.
PMID: 38652658
Glioblastoma (GBM) is a deadly brain tumor, and the kinesin motor KIF11 is an attractive therapeutic target with roles in proliferation and invasion. Resistance to KIF11 inhibitors, which has mainly...
6.
Goldberg A, Dovas A, Torres D, Das Sharma S, Mela A, Merricks E, et al.
bioRxiv
. 2024 Jan;
PMID: 38293120
Gliomas are highly aggressive brain tumors characterized by poor prognosis and composed of diffusely infiltrating tumor cells that intermingle with non-neoplastic cells in the tumor microenvironment, including neurons. Neurons are...
7.
A novel mechanoeffector role of fibroblast S100A4 in myofibroblast transdifferentiation and fibrosis
Southern B, Li H, Mao H, Crish J, Grove L, Scheraga R, et al.
J Biol Chem
. 2023 Dec;
300(1):105530.
PMID: 38072048
Fibroblast to myofibroblast transdifferentiation mediates numerous fibrotic disorders, such as idiopathic pulmonary fibrosis (IPF). We have previously demonstrated that non-muscle myosin II (NMII) is activated in response to fibrotic lung...
8.
Cheng Y, Banu M, Zhao W, Rosenfeld S, Canoll P, Sims P
bioRxiv
. 2023 Sep;
PMID: 37745469
Glioblastoma (GBM) is a deadly brain tumor, and the kinesin motor KIF11 is an attractive therapeutic target because of its dual roles in proliferation and invasion. The clinical utility of...
9.
Ranaivoson F, Crozet V, Benoit M, Abdalla Mohammed Khalid A, Kikuti C, Sirkia H, et al.
Open Biol
. 2023 Sep;
13(9):230122.
PMID: 37726093
KIF20A is a critical kinesin for cell division and a promising anti-cancer drug target. The mechanisms underlying its cellular roles remain elusive. Interestingly, unusual coupling between the nucleotide- and microtubule-binding...
10.
Nithianantham S, Iwanski M, Gaska I, Pandey H, Bodrug T, Inagaki S, et al.
Mol Biol Cell
. 2023 Aug;
34(11):ar111.
PMID: 37610838
Kinesin-5 crosslinks and slides apart microtubules to assemble, elongate, and maintain the mitotic spindle. Kinesin-5 is a tetramer, where two N-terminal motor domains are positioned at each end of the...