Steven S Gonzales
Overview
Explore the profile of Steven S Gonzales including associated specialties, affiliations and a list of published articles.
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Articles
2
Citations
19
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Recent Articles
1.
Thomas A, De Meese J, Le Huerou Y, Boyd S, Romoff T, Gonzales S, et al.
Bioorg Med Chem Lett
. 2008 Jan;
18(2):509-12.
PMID: 18182286
Inhibition of the thiamine-utilizing enzyme transketolase (TK) has been linked with diminished tumor cell proliferation. Most thiamine antagonists have a permanent positive charge on the B-ring, and it has been...
2.
Le Huerou Y, Gunawardana I, Thomas A, Boyd S, De Meese J, DeWolf W, et al.
Bioorg Med Chem Lett
. 2007 Dec;
18(2):505-8.
PMID: 18083562
Transketolase, a key enzyme in the pentose phosphate pathway, has been suggested as a target for inhibition in the treatment of cancer. Compound 5a ('N3'-pyridyl thiamine'; 3-(6-methyl-2-amino-pyridin-3-ylmethyl)-5-(2-hydroxy-ethyl)-4-methyl-thiazol-3-ium chloride hydrochloride), an...