Steven M Rothman
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Explore the profile of Steven M Rothman including associated specialties, affiliations and a list of published articles.
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Recent Articles
11.
Yang X, Rode D, Peterka D, Yuste R, Rothman S
Ann Neurol
. 2012 Jan;
71(1):68-75.
PMID: 22275253
Objective: There is enormous clinical potential in exploiting the spatial and temporal resolution of optical techniques to modulate pathophysiological neuronal activity, especially intractable focal epilepsy. We have recently utilized a...
12.
Orchard P, Lund T, Miller W, Rothman S, Raymond G, Nascene D, et al.
J Neuroinflammation
. 2011 Oct;
8:144.
PMID: 22014002
Background: Adrenoleukodystrophy (ALD) is an X-linked peroxisomal disorder characterized by the abnormal beta-oxidation of very long chain fatty acids (VLCFA). In 35-40% of children with ALD, an acute inflammatory process...
13.
Smyth M, Rothman S
Neurosurg Clin N Am
. 2011 Sep;
22(4):533-46, vii.
PMID: 21939851
Focal cooling may provide a safe, nondestructive alternative to resective and disconnective strategies that have been proposed or used to control refractory epilepsy. Observations of the effects of direct application...
14.
Meehan A, Yang X, McAdams B, Yuan L, Rothman S
J Neurophysiol
. 2011 Jun;
106(3):1227-39.
PMID: 21653714
Levetiracetam (LEV) is one of the most commonly prescribed antiepileptic drugs, but its mechanism of action is uncertain. Based on prior information that LEV binds to the vesicular protein synaptic...
15.
Miller W, Rothman S, Nascene D, Kivisto T, DeFor T, Ziegler R, et al.
Blood
. 2011 May;
118(7):1971-8.
PMID: 21586746
Cerebral adrenoleukodystrophy (cALD) remains a devastating neurodegenerative disease; only allogeneic hematopoietic cell transplantation (HCT) has been shown to provide long-term disease stabilization and survival. Sixty boys undergoing HCT for cALD...
16.
Moore B, Rothman S, Clark H, Vehe R, Laguna T
Pediatr Neurol
. 2010 Aug;
43(1):49-52.
PMID: 20682204
Wegener's granulomatosis is a necrotizing, granulomatous vasculitis that primarily affects the respiratory tract and kidneys. It is rare in children. Few pediatric and adult case reports described seizures and central...
17.
Yang X, Schmidt B, Rode D, Rothman S
Epilepsia
. 2009 Aug;
51(1):127-35.
PMID: 19674053
Purpose: To determine if a small ultraviolet emitting diode (UV LED) could release sufficient gamma-aminobutyric acid (GABA) from a caged precursor to suppress paroxysmal activity in rat brain slices. Methods:...
18.
Yang X, Rothman S
Seizure
. 2009 Aug;
18(9):615-9.
PMID: 19651528
We recently reported that rodent hippocampal slices incubated with levetiracetam for 3h had altered responses to repetitive stimulation and reduced neurotransmitter release. However, our experiments failed to determine the actual...
19.
Rothman S
Neurotherapeutics
. 2009 Apr;
6(2):251-7.
PMID: 19332317
The therapy of the focal cortical epilepsies remains unsatisfactory. Close to a third of patients fail to gain adequate control with antiepileptic drugs and a portion of those who do,...
20.
Xu L, Rensing N, Yang X, Zhang H, Thio L, Rothman S, et al.
J Clin Invest
. 2007 Dec;
118(1):272-80.
PMID: 18097472
Leptin is a hormone that reduces excitability in some hypothalamic neurons via leptin receptor activation of the JAK2 and PI3K intracellular signaling pathways. We hypothesized that leptin receptor activation in...