Steven M Harwood
Overview
Explore the profile of Steven M Harwood including associated specialties, affiliations and a list of published articles.
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12
Citations
254
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Recent Articles
1.
Kieswich J, Sayers S, Silvestre M, Harwood S, Yaqoob M, Caton P
Diabetologia
. 2016 Aug;
59(11):2477-2486.
PMID: 27541013
Aims/hypothesis: Serum extracellular nicotinamide phosphoribosyltransferase (eNAMPT) concentrations are elevated in type 2 diabetes. However, the relationship between abnormally elevated serum eNAMPT and type 2 diabetes pathophysiology is unclear. eNAMPT circulates...
2.
Chesser A, Harwood S, Raftery M, Yaqoob M
Int J Nephrol Renovasc Dis
. 2016 Jun;
9:129-37.
PMID: 27307758
Purpose: Cardiac bioenergetics are known to be abnormal in experimental uremia as exemplified by a reduced phosphocreatine (PCr)/adenosine triphosphate (ATP) ratio. However, the progression of these bioenergetic changes during the...
3.
Andrikopoulos P, Kieswich J, Harwood S, Baba A, Matsuda T, Barbeau O, et al.
J Biol Chem
. 2015 May;
290(30):18412-28.
PMID: 25979335
Thrombin acts on the endothelium by activating protease-activated receptors (PARs). The endothelial thrombin-PAR system becomes deregulated during pathological conditions resulting in loss of barrier function and a pro-inflammatory and pro-angiogenic...
4.
White W, Yaqoob M, Harwood S
World J Nephrol
. 2015 Feb;
4(1):19-30.
PMID: 25664244
Many observers have noted that the morphological changes that occur in chronic kidney disease (CKD) patients resemble those seen in the geriatric population, with strikingly similar morbidity and mortality profiles...
5.
Dreyer G, Tucker A, Harwood S, Pearse R, Raftery M, Yaqoob M
PLoS One
. 2014 Jul;
9(7):e99461.
PMID: 25006678
Background And Objectives: Vitamin D deficiency and endothelial dysfunction are non-traditional risk factors for cardiovascular events in chronic kidney disease. Previous studies in chronic kidney disease have failed to demonstrate...
6.
Chapagain A, Caton P, Kieswich J, Andrikopoulos P, Nayuni N, Long J, et al.
Proc Natl Acad Sci U S A
. 2014 Feb;
111(10):3817-22.
PMID: 24569863
Insulin resistance and associated metabolic sequelae are common in chronic kidney disease (CKD) and are positively and independently associated with increased cardiovascular mortality. However, the pathogenesis has yet to be...
7.
Shah S, Harwood S, Dohler B, Opelz G, Yaqoob M
Transplantation
. 2012 Sep;
94(5):486-91.
PMID: 22960765
Background: Interindividual variation in inosine monophosphate dehydrogenase (IMPDH) enzyme activity and adverse effects caused by mycophenolate mofetil (MMF) inhibition may be genetically determined, and if so, transplant recipients should receive...
8.
Harwood S, Yaqoob M, Allen D
Ann Clin Biochem
. 2005 Nov;
42(Pt 6):415-31.
PMID: 16259792
Calpain and caspase are families of cysteine proteases that have important roles in the initiation, regulation and execution of cell death. The function of both groups of proteases in the...
9.
Allen D, Yaqoob M, Harwood S
J Nutr Biochem
. 2005 Sep;
16(12):705-13.
PMID: 16169208
Cellular responses to high glucose are numerous and varied but ultimately result in functional changes and, often, cell death. High glucose induces oxidative and nitrosative stress in many cell types...
10.
Ashman N, Harwood S, Kieswich J, Allen D, Roberts N, Mendes-Ribeiro A, et al.
Kidney Int
. 2005 Apr;
67(5):1878-89.
PMID: 15840035
Background: Pure albumin stimulates proximal tubular epithelial cell (PTEC) proliferation, and may have a role in homeostasis in health, as well as in disrupted PTEC turnover in proteinuric nephropathies. We...