Steven M Frisch
Overview
Explore the profile of Steven M Frisch including associated specialties, affiliations and a list of published articles.
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25
Citations
1288
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Recent Articles
11.
Cieply B, Farris J, Denvir J, Ford H, Frisch S
Cancer Res
. 2013 Aug;
73(20):6299-309.
PMID: 23943797
Epithelial-mesenchymal transition (EMT) in carcinoma cells enhances malignant progression by promoting invasion and survival. EMT is induced by microenvironmental factors, including TGF-β and Wnt agonists, and by the E-box-binding transcription...
12.
Park S, Riley 4th P, Frisch S
Apoptosis
. 2013 Apr;
18(8):949-62.
PMID: 23588592
Anoikis-resistance of tumor cells is critical for anchorage-independent growth and metastasis. The inflammatory-response transcription factor NF-κB contributes to anoikis-resistance and tumor progression through mechanisms that are understood incompletely. Deleted in...
13.
Frisch S, Schaller M, Cieply B
J Cell Sci
. 2013 Mar;
126(Pt 1):21-9.
PMID: 23516327
The oncogenic epithelial-mesenchymal transition (EMT) contributes to tumor progression in various context-dependent ways, including increased metastatic potential, expansion of cancer stem cell subpopulations, chemo-resistance and disease recurrence. One of the...
14.
Cieply B, Riley 4th P, Pifer P, Widmeyer J, Addison J, Ivanov A, et al.
Cancer Res
. 2012 Mar;
72(9):2440-53.
PMID: 22379025
Grainyhead genes are involved in wound healing and developmental neural tube closure. In light of the high degree of similarity between the epithelial-mesenchymal transitions (EMT) occurring in wound-healing processes and...
15.
Kumar S, Park S, Cieply B, Schupp J, Killiam E, Zhang F, et al.
Mol Cell Biol
. 2011 Jul;
31(19):4036-51.
PMID: 21746881
Detachment of epithelial cells from matrix or attachment to an inappropriate matrix engages an apoptotic response known as anoikis, which prevents metastasis. Cellular sensitivity to anoikis is compromised during the...
16.
Schaller M, Frisch S
Cancer Biol Ther
. 2010 Apr;
9(10):791-3.
PMID: 20364110
No abstract available.
17.
Frisch S
Cancer Res
. 2008 Jun;
68(12):4491-3.
PMID: 18559490
Recent studies have revealed that procaspase-8 has an important function in cell adhesion and motility. Src phosphorylation controls this function by preventing the conversion of procaspase-8, which is an adhesion/migration...
18.
Senft J, Helfer B, Frisch S
Cancer Res
. 2007 Dec;
67(24):11505-9.
PMID: 18089778
Cell migration plays an important role in tumor cell invasion and metastasis. Previously, we reported that caspase-8 contributes to cell migration and adhesion, a novel nonapoptotic function of an established...
19.
Huang X, Masselli A, Frisch S, Hunton I, Jiang Y, Wang J
J Biol Chem
. 2007 Aug;
282(40):29401-13.
PMID: 17686781
Tumor necrosis factor-alpha (TNF) activates caspase-8 to cleave effector caspases or Bid, resulting in type-1 or type-2 apoptosis, respectively. We show here that TNF also induces caspase-8-dependent C-terminal cleavage of...
20.
Helfer B, Boswell B, Finlay D, Cipres A, Vuori K, Kang T, et al.
Cancer Res
. 2006 Apr;
66(8):4273-8.
PMID: 16618751
Significant caspase-8 activity has been found in normal and certain tumor cells, suggesting that caspase-8 possesses an alternative, nonapoptotic function that may contribute to tumor progression. In this article, we...