Steven M Colegate
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Explore the profile of Steven M Colegate including associated specialties, affiliations and a list of published articles.
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30
Citations
214
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Recent Articles
1.
Edgar J, Molyneux R, Colegate S
Chem Res Toxicol
. 2022 Mar;
35(3):340-354.
PMID: 35238548
Sporadic motor neuron diseases (MNDs), such as amyotrophic lateral sclerosis (ALS), can be caused by spontaneous genetic mutations. However, many sporadic cases of ALS and other debilitating neurodegenerative diseases (NDDs)...
2.
Edgar J, Molyneux R, Colegate S
J Agric Food Chem
. 2020 May;
68(22):5995-5997.
PMID: 32432873
No abstract available.
3.
Stegelmeier B, Colegate S, Knoppel E, Rood K, Collett M
Toxicon
. 2019 Jun;
167:60-66.
PMID: 31173794
Wild parsnip (Pastinaca sativa) has been associated with livestock and human photosensitization. An investigation of a natural occurrence of photosensitization of grazing horses identified wild parsnip as a possible cause....
4.
Colegate S, Upton R, Gardner D, Panter K, Betz J
Phytochem Anal
. 2018 Jul;
29(6):613-626.
PMID: 29968391
Introduction: Pro-toxic dehydropyrrolizidine alkaloids are associated with liver disease in humans. The potential for long-term, low-level or intermittent exposures to cause or contribute to chronically-developing diseases is of international concern....
5.
Stegelmeier B, Colegate S, Brown A
Toxins (Basel)
. 2016 Dec;
8(12).
PMID: 27916846
Dehydropyrrolizidine alkaloid (DHPA)-producing plants have a worldwide distribution amongst flowering plants and commonly cause poisoning of livestock, wildlife, and humans. Previous work has produced considerable understanding of DHPA metabolism, toxicity,...
6.
Colegate S, Gardner D, Betz J, Fischer O, Liede-Schumann S, Boppre M
Phytochem Anal
. 2016 Jul;
27(5):257-76.
PMID: 27432636
Introduction: Within the Apocynoideae (Apocynaceae) pro-toxic dehydropyrrolizidine alkaloids have been reported only in Echiteae. However, attraction of pyrrolizidine alkaloid-pharmacophagous insects suggested their presence in Alafia cf. caudata Stapf (Nerieae: Alafiinae)...
7.
Brown A, Stegelmeier B, Colegate S, Gardner D, Panter K, Knoppel E, et al.
J Appl Toxicol
. 2015 Jul;
36(5):716-25.
PMID: 26177929
Comfrey (Symphytum officinale), a commonly used herb, contains dehydropyrrolizidine alkaloids that, as a group of bioactive metabolites, are potentially hepatotoxic, pneumotoxic, genotoxic and carcinogenic. Consequently, regulatory agencies and international health...
8.
Colegate S, Boppre M, Monzon J, Betz J
J Ethnopharmacol
. 2015 Jun;
172:179-94.
PMID: 26087231
Ethnopharmacological Relevance: Asmachilca is a Peruvian medicinal herb preparation ostensibly derived from Aristeguietia gayana (Wedd.) R.M. King & H. Rob. (Asteraceae: Eupatorieae). Decoctions of the plant have a reported bronchodilation...
9.
Brown A, Stegelmeier B, Colegate S, Panter K, Knoppel E, Hall J
J Appl Toxicol
. 2015 Feb;
35(12):1557-63.
PMID: 25690669
Dehydropyrrolizidine alkaloids (DHPA) are a large, structurally diverse group of plant-derived protoxins that are potentially carcinogenic. With worldwide significance, these alkaloids can contaminate or be naturally present in the human...
10.
Field R, Stegelmeier B, Colegate S, Brown A, Green B
Toxicon
. 2015 Feb;
97:36-45.
PMID: 25666399
Plants producing dehydropyrrolizidine alkaloids (DHPAs) are found throughout the world and they are dangerous to human and animal health. Several DHPAs are carcinogenic but only riddelliine has been classified as...