Steven K Engle
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Explore the profile of Steven K Engle including associated specialties, affiliations and a list of published articles.
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12
Citations
411
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Recent Articles
1.
Agostinucci K, Manfredi T, Cosmas A, Vetter F, Engle S
Toxicol Pathol
. 2022 May;
50(4):497-506.
PMID: 35608026
Atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP) are cardiac hormones located in atria granules. Both peptides respond to cardiac pressure and volume dynamics and accordingly serve as translation...
2.
Kim K, Chini N, Fairchild D, Engle S, Reagan W, Summers S, et al.
Toxicol Pathol
. 2016 Sep;
44(8):1072-1083.
PMID: 27638646
There is a great need for improved diagnostic and prognostic accuracy of potential cardiac toxicity in drug development. This study reports the evaluation of several commercially available biomarker kits by...
3.
Dunn M, Manfredi T, Agostinucci K, Engle S, Powe J, King N, et al.
Toxicol Pathol
. 2016 Apr;
45(2):344-352.
PMID: 27102652
Given the proven utility of natriuretic peptides as serum biomarkers of cardiovascular maladaptation and dysfunction in humans and the high cross-species sequence conservation of atrial natriuretic peptides, natriuretic peptides have...
4.
Engle S, Watson D
Toxicol Sci
. 2015 Nov;
149(2):458-72.
PMID: 26609138
Cardiovascular (CV) toxicity is an important cause of failure during drug development. Blood-based biomarkers can be used to detect CV toxicity during preclinical development and prioritize compounds at lower risk...
5.
Vinken P, Reagan W, Rodriguez L, Buck W, Lai-Zhang J, Goeminne N, et al.
J Pharmacol Toxicol Methods
. 2015 Oct;
77:58-65.
PMID: 26516096
Introduction: Natriuretic peptides, including N-terminal-proatrial natriuretic peptide (NT-proANP) are cardiac hormones that are produced in response to myocardial stretch and have been used in rats and humans as blood based...
6.
Usborne A, Smith A, Engle S, Watson D, Sullivan J, Walgren J
Toxicol Pathol
. 2013 Nov;
42(1):195-203.
PMID: 24285669
Unlabelled: Consistent, sensitive biomarkers of exocrine pancreatic injury (EPIJ) in animal models and humans have historically represented a poorly met need for investigators and clinicians. Experimental Design: Sprague-Dawley CD/International Genetic...
7.
Engle S, Solter P, Credille K, Bull C, Adams S, Berna M, et al.
Toxicol Sci
. 2010 Jan;
114(2):183-92.
PMID: 20044590
Chronic treatment with suprapharmacologic doses of peroxisome proliferator-activated receptor (PPAR) agonists has a known potential for causing left ventricular hypertrophy (LVH). The mechanism by which LVH develops is not well...
8.
Engle S, Jordan W, Pritt M, Chiang A, Davis M, Zimmermann J, et al.
Toxicol Pathol
. 2009 Jun;
37(5):617-28.
PMID: 19549929
Cardiac troponin I is a useful biomarker of myocardial injury, but its use in mice and application to early drug discovery are not well described. The authors investigated the relationship...
9.
Saha J, Xia J, Engle S, Chen Y, Glaesner W, Jakubowski J
J Pharmacol Exp Ther
. 2005 Nov;
316(3):1159-64.
PMID: 16280413
A rodent model of controlled acute hyperglycemia that is sensitive to glucose-lowering agents insulin and glucagon-like peptide-1 (GLP-1) analog has been developed. The studies show that anesthesia could be induced...
10.
Saha J, Xia J, Grondin J, Engle S, Jakubowski J
Exp Biol Med (Maywood)
. 2005 Oct;
230(10):777-84.
PMID: 16246906
The effects of anesthetic agents, commonly used in animal models, on blood glucose levels in fed and fasted rats were investigated. In fed Sprague-Dawley rats, ketamine (100 mg/kg)/xylazine (10 mg/kg)...