Steven J Hersch
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Explore the profile of Steven J Hersch including associated specialties, affiliations and a list of published articles.
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Articles
13
Citations
405
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Recent Articles
1.
Hersch S, Chandrasekaran S, Lam J, Nafissi N, Slavcev R
Mol Ther Methods Clin Dev
. 2024 Mar;
32(2):101227.
PMID: 38516691
Biotechnologies such as gene therapy have brought DNA vectors to the forefront of pharmaceuticals. The quality of starting material plays a pivotal role in determining final product quality. Here, we...
2.
Hersch S, Lam L, Dong T
mBio
. 2021 Jul;
12(4):e0111521.
PMID: 34281388
Genetic editing has revolutionized biotechnology, but delivery of endonuclease genes as DNA can lead to aberrant integration or overexpression, leading to off-target effects. Here, we develop a mechanism to deliver...
3.
Manera K, Caro F, Li H, Pei T, Hersch S, Mekalanos J, et al.
Proc Natl Acad Sci U S A
. 2021 Jun;
118(25).
PMID: 34161288
The type 6 secretion system (T6SS) is a bacterial weapon broadly distributed in gram-negative bacteria and used to kill competitors and predators. Featuring a long and double-tubular structure, this molecular...
4.
Hersch S, Radan B, Ilyas B, Lavoie P, Navarre W
J Bacteriol
. 2021 Feb;
203(9).
PMID: 33593945
Bacteria have evolved to sense and respond to their environment by altering gene expression and metabolism to promote growth and survival. In this work we demonstrate that displays an extensive...
5.
Hersch S, Manera K, Dong T
Cell Rep
. 2020 Oct;
33(2):108259.
PMID: 33053336
The bacterial type six secretion system (T6SS) delivers toxic effector proteins into neighboring cells, but bacteria must protect themselves against their own T6SS. Immunity genes are the best-characterized defenses, protecting...
6.
Hersch S, Navarre W
Infect Immun
. 2020 Jul;
88(10).
PMID: 32719152
Itaconate is a dicarboxylic acid that inhibits the isocitrate lyase enzyme of the bacterial glyoxylate shunt. Activated macrophages have been shown to produce itaconate, suggesting that these immune cells may...
7.
Kamal F, Liang X, Manera K, Pei T, Kim H, Lam L, et al.
Cell Rep
. 2020 Jun;
31(11):107766.
PMID: 32553162
The type VI secretion system (T6SS) is a lethal microbial weapon that injects a large needle-like structure carrying toxic effectors into recipient cells through physical penetration. How recipients respond to...
8.
Hersch S, Watanabe N, Stietz M, Manera K, Kamal F, Burkinshaw B, et al.
Nat Microbiol
. 2020 Feb;
5(5):706-714.
PMID: 32094588
The arms race among microorganisms is a key driver in the evolution of not only the weapons but also defence mechanisms. Many Gram-negative bacteria use the type six secretion system...
9.
Hersch S, Elgamal S, Katz A, Ibba M, Navarre W
J Biol Chem
. 2014 Aug;
289(41):28160-71.
PMID: 25148683
Ribosome stalling during translation can be caused by a number of characterized mechanisms. However, the impact of elongation stalls on protein levels is variable, and the reasons for this are...
10.
Elgamal S, Katz A, Hersch S, Newsom D, White P, Navarre W, et al.
PLoS Genet
. 2014 Aug;
10(8):e1004553.
PMID: 25144653
Elongation factor P (EF-P) is required for the efficient synthesis of proteins with stretches of consecutive prolines and other motifs that would otherwise lead to ribosome pausing. However, previous reports...