Steven Havlicek
Overview
Explore the profile of Steven Havlicek including associated specialties, affiliations and a list of published articles.
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16
Citations
546
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Recent Articles
1.
Gupta R, Dittmeier M, Wohlleben G, Nickl V, Bischler T, Luzak V, et al.
Cancer Gene Ther
. 2024 Jul;
31(9):1357-1379.
PMID: 39039193
Trk (NTRK) receptor and NTRK gene fusions are oncogenic drivers of a wide variety of tumors. Although Trk receptors are typically activated at the cell surface, signaling of constitutive active...
2.
Bershteyn M, Broer S, Parekh M, Maury Y, Havlicek S, Kriks S, et al.
Cell Stem Cell
. 2023 Oct;
30(10):1331-1350.e11.
PMID: 37802038
Mesial temporal lobe epilepsy (MTLE) is the most common focal epilepsy. One-third of patients have drug-refractory seizures and are left with suboptimal therapeutic options such as brain tissue-destructive surgery. Here,...
3.
Murray A, Gough G, Cindric A, Vuckovic F, Koschut D, Borelli V, et al.
EBioMedicine
. 2023 Jul;
94:104692.
PMID: 37451904
Background: People with Down syndrome (DS) show clinical signs of accelerated ageing. Causative mechanisms remain unknown and hypotheses range from the (essentially untreatable) amplified-chromosomal-instability explanation, to potential actions of individual...
4.
Alic I, Goh P, Murray A, Portelius E, Gkanatsiou E, Gough G, et al.
Mol Psychiatry
. 2021 Jul;
26(10):5789.
PMID: 34272490
No abstract available.
5.
Alic I, Goh P, Murray A, Portelius E, Gkanatsiou E, Gough G, et al.
Mol Psychiatry
. 2020 Jul;
26(10):5766-5788.
PMID: 32647257
A population of more than six million people worldwide at high risk of Alzheimer's disease (AD) are those with Down Syndrome (DS, caused by trisomy 21 (T21)), 70% of whom...
6.
Stamou M, Ng S, Brand H, Wang H, Plummer L, Best L, et al.
J Clin Endocrinol Metab
. 2019 Oct;
105(3).
PMID: 31628846
Context: Kallmann syndrome (KS) is a rare, genetically heterogeneous Mendelian disorder. Structural defects in KS patients have helped define the genetic architecture of gonadotropin-releasing hormone (GnRH) neuronal development in this...
7.
Prots I, Grosch J, Brazdis R, Simmnacher K, Veber V, Havlicek S, et al.
Proc Natl Acad Sci U S A
. 2018 Jul;
115(30):7813-7818.
PMID: 29991596
α-Synuclein (α-Syn) aggregation, proceeding from oligomers to fibrils, is one central hallmark of neurodegeneration in synucleinopathies. α-Syn oligomers are toxic by triggering neurodegenerative processes in in vitro and in vivo...
8.
Havlicek S, Shen Y, Alpagu Y, Bruntraeger M, Zufir N, Phuah Z, et al.
Mol Ther
. 2017 Feb;
25(2):342-355.
PMID: 28153087
Clustered regularly interspaced palindromic repeats (CRISPR)/Cas9 enables us to generate targeted sequence changes in the genomes of cells and organisms. However, off-target effects have been a persistent problem hampering the...
9.
Mishra H, Prots I, Havlicek S, Kohl Z, Perez-Branguli F, Boerstler T, et al.
Ann Neurol
. 2016 Mar;
79(5):826-840.
PMID: 26971897
Objective: Mutations in the spastic paraplegia gene 11 (SPG11), encoding spatacsin, cause the most frequent form of autosomal-recessive complex hereditary spastic paraplegia (HSP) and juvenile-onset amyotrophic lateral sclerosis (ALS5). When...
10.
Eberhardt E, Havlicek S, Schmidt D, Link A, Neacsu C, Kohl Z, et al.
Stem Cell Reports
. 2015 Sep;
5(3):305-13.
PMID: 26321143
Human pluripotent stem cells (hPSCs) offer the opportunity to generate neuronal cells, including nociceptors. Using a chemical-based approach, we generated nociceptive sensory neurons from HUES6 embryonic stem cells and retrovirally...