Steven Hamley
Overview
Explore the profile of Steven Hamley including associated specialties, affiliations and a list of published articles.
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10
Citations
168
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Recent Articles
1.
Bruce C, Hamley S, Ang T, Howlett K, Shaw C, Kowalski G
Mol Metab
. 2021 Jun;
53:101281.
PMID: 34175474
Objective: The glucose tolerance test (GTT) is widely used in human and animal biomedical and pharmaceutical research. Despite its prevalent use, particularly in mouse metabolic phenotyping, to the best of...
2.
Beyene H, Hamley S, Giles C, Huynh K, Smith A, Cinel M, et al.
J Clin Endocrinol Metab
. 2020 Feb;
105(3).
PMID: 32016362
Context: Insulin resistance (IR) remains a global health challenge. Lipidomics offers an opportunity to identify biomarkers and better understand mechanisms of IR associated with abnormal lipid metabolism. Objective: The objective...
3.
Hamley S, Kloosterman D, Duthie T, Dalla Man C, Visentin R, Mason S, et al.
Diabetologia
. 2019 Sep;
62(12):2310-2324.
PMID: 31489455
Aims/hypothesis: This study aimed to examine the metabolic health of young apparently healthy non-obese adults to better understand mechanisms of hyperinsulinaemia. Methods: Non-obese (BMI < 30 kg/m) adults aged 18-35 ...
4.
Selathurai A, Kowalski G, Mason S, Callahan D, Foletta V, Della Gatta P, et al.
Mol Metab
. 2019 Jul;
27:33-46.
PMID: 31285171
Objective: Phosphatidylethanolamine (PtdEtn) is a major phospholipid in mammals. It is synthesized via two pathways, the CDP-ethanolamine pathway in the endoplasmic reticulum and the phosphatidylserine (PtdSer) decarboxylase (PSD) pathway in...
5.
Kowalski G, Moore S, Hamley S, Selathurai A, Bruce C
Diabetes
. 2017 Jul;
66(9):2400-2406.
PMID: 28684634
Insulin clamp studies have shown that the suppressive actions of insulin on endogenous glucose production (EGP) are markedly more sensitive than for stimulating glucose disposal (). However, clamp conditions do...
6.
Hamley S
Nutr J
. 2017 May;
16(1):30.
PMID: 28526025
Background: A cornerstone of conventional dietary advice is the recommendation to replace saturated fatty acids (SFA) with mostly n-6 polyunsaturated fatty acids (PUFA) to reduce the risk of coronary heart...
7.
Kowalski G, Hamley S, Selathurai A, Kloehn J, de Souza D, OCallaghan S, et al.
Sci Rep
. 2016 Jun;
6:27541.
PMID: 27273128
In humans, low-energy diets rapidly reduce hepatic fat and improve/normalise glycemic control. Due to difficulties in obtaining human liver, little is known about changes to the lipid species and pathway...
8.
Kowalski G, de Souza D, Risis S, Burch M, Hamley S, Kloehn J, et al.
Biochem Biophys Res Commun
. 2015 Jun;
463(4):818-24.
PMID: 26086096
Rationale: Cardiac metabolism is thought to be altered in insulin resistance and type 2 diabetes (T2D). Our understanding of the regulation of cardiac substrate metabolism and insulin sensitivity has largely...
9.
Kowalski G, de Souza D, Burch M, Hamley S, Kloehn J, Selathurai A, et al.
Biochem Biophys Res Commun
. 2015 May;
462(1):27-32.
PMID: 25930998
Rationale: Defects in muscle glucose metabolism are linked to type 2 diabetes. Mechanistic studies examining these defects rely on the use of high fat-fed rodent models and typically involve the...
10.
Kowalski G, Kloehn J, Burch M, Selathurai A, Hamley S, Bayol S, et al.
Biochim Biophys Acta
. 2014 Dec;
1851(2):210-9.
PMID: 25490466
Hepatic insulin resistance is a major risk factor for the development of type 2 diabetes and is associated with the accumulation of lipids, including diacylglycerol (DAG), triacylglycerols (TAG) and ceramide....