Steven G Sedgwick
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Explore the profile of Steven G Sedgwick including associated specialties, affiliations and a list of published articles.
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11
Citations
536
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Recent Articles
1.
Geymonat M, Spanos A, Jensen S, Sedgwick S
J Cell Biol
. 2010 Dec;
191(6):1097-112.
PMID: 21149565
Lte1 is known as a regulator of mitotic progression in budding yeast. Here we demonstrate phosphorylation-dependent inhibition of polarized bud growth during G2/M by Lte1. Cla4 activity first localizes Lte1...
2.
Papadopoulou K, Chen J, Mead E, Feoktistova A, Petit C, Agarwal M, et al.
J Cell Sci
. 2010 Nov;
123(Pt 24):4374-81.
PMID: 21098641
Regulated gene expression makes an important contribution to cell cycle control mechanisms. In fission yeast, a group of genes is coordinately expressed during a late stage of the cell cycle...
3.
Geymonat M, Spanos A, de Bettignies G, Sedgwick S
J Cell Biol
. 2009 Dec;
187(4):497-511.
PMID: 19948498
Lte1 is a mitotic regulator long envisaged as a guanosine nucleotide exchange factor (GEF) for Tem1, the small guanosine triphosphatase governing activity of the Saccharomyces cerevisiae mitotic exit network. We...
4.
Carballo J, Johnson A, Sedgwick S, Cha R
Cell
. 2008 Mar;
132(5):758-70.
PMID: 18329363
An essential feature of meiosis is interhomolog recombination whereby a significant fraction of the programmed meiotic double-strand breaks (DSBs) is repaired using an intact homologous non-sister chromatid rather than a...
5.
Papadopoulou K, Ng S, Ohkura H, Geymonat M, Sedgwick S, McInerny C
J Cell Sci
. 2007 Dec;
121(Pt 1):38-47.
PMID: 18057023
In fission yeast the expression of several genes during M-G1 phase is controlled by binding of the PCB binding factor (PBF) transcription factor complex to Pombe cell cycle box (PCB)...
6.
Geymonat M, Spanos A, Sedgwick S
Gene
. 2007 Jun;
399(2):120-8.
PMID: 17566670
Yeasts are attractive organisms for recombinant protein production. They combine highly developed genetic systems and ease of use with reductions in time and costs. We describe an autoselection system for...
7.
Darieva Z, Bulmer R, Pic-Taylor A, Doris K, Geymonat M, Sedgwick S, et al.
Nature
. 2006 Nov;
444(7118):494-8.
PMID: 17122856
Polo kinases have crucial conserved functions in controlling the eukaryotic cell cycle through orchestrating several events during mitosis. An essential element of cell cycle control is exerted by altering the...
8.
Geymonat M, Spanos A, Wells G, Smerdon S, Sedgwick S
Mol Cell Biol
. 2004 Mar;
24(6):2277-85.
PMID: 14993267
Nuclear export of the transcription factor Swi6 during the budding yeast Saccharomyces cerevisiae cell cycle is known to require phosphorylation of the Swi6 serine 160 residue. We show that Clb6/Cdc28...
9.
Darieva Z, Pic-Taylor A, Boros J, Spanos A, Geymonat M, Reece R, et al.
Curr Biol
. 2003 Oct;
13(19):1740-5.
PMID: 14521842
Recent studies in Saccharomyces cerevisiae by using global approaches have significantly enhanced our knowledge of the components involved in the transcriptional regulation of the cell cycle. The Mcm1p-Fkh2p complex, in...
10.
Geymonat M, Spanos A, Walker P, Johnston L, Sedgwick S
J Biol Chem
. 2003 Mar;
278(17):14591-4.
PMID: 12637549
The Cdc5 protein of budding yeast is a polo-like kinase that has multiple roles in mitosis including control of the mitotic exit network (MEN). MEN activity brings about loss of...