Steven E Hyman
Overview
Explore the profile of Steven E Hyman including associated specialties, affiliations and a list of published articles.
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87
Citations
8039
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Recent Articles
1.
Wang J, Jiang C, Guo Z, Chapman S, Kozhemiako N, Mylonas D, et al.
BMC Psychiatry
. 2024 Jun;
24(1):433.
PMID: 38858652
Background: Objective and quantifiable markers are crucial for developing novel therapeutics for mental disorders by 1) stratifying clinically similar patients with different underlying neurobiological deficits and 2) objectively tracking disease...
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Krainc D, Martin W, Casey B, Jensen F, Tishkoff S, Potter W, et al.
Sci Transl Med
. 2024 Jan;
15(720):eadg4775.
PMID: 38190501
Clinical trials for central nervous system disorders often enroll patients with unrecognized heterogeneous diseases, leading to costly trials that have high failure rates. Here, we discuss the potential of emerging...
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Kotov R, Cicero D, Conway C, DeYoung C, Dombrovski A, Eaton N, et al.
Psychol Med
. 2022 Jun;
52(9):1666-1678.
PMID: 35650658
The Hierarchical Taxonomy of Psychopathology (HiTOP) has emerged out of the quantitative approach to psychiatric nosology. This approach identifies psychopathology constructs based on patterns of co-variation among signs and symptoms....
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Trubetskoy V, Pardinas A, Qi T, Panagiotaropoulou G, Awasthi S, Bigdeli T, et al.
Nature
. 2022 Apr;
604(7906):502-508.
PMID: 35396580
Schizophrenia has a heritability of 60-80%, much of which is attributable to common risk alleles. Here, in a two-stage genome-wide association study of up to 76,755 individuals with schizophrenia and...
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Hyman S
Curr Opin Genet Dev
. 2021 May;
68:99-105.
PMID: 33957550
Human genetics is providing much needed clues to mechanisms underlying neuropsychiatric disorders. Highly penetrant copy number variants (CNVs) were among the first genetic variants confidently associated with schizophrenia and autism...
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Hyman S
Perspect Biol Med
. 2021 Mar;
64(1):6-28.
PMID: 33746127
The third edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-III) and its descriptive psychiatry-based intellectual antecedents imagined psychiatric disorders as discontinuous categories, presumably natural kinds, that would...
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