Steven E Calvano
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Explore the profile of Steven E Calvano including associated specialties, affiliations and a list of published articles.
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9
Citations
792
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Recent Articles
1.
Mavroudis P, Corbett S, Calvano S, Androulakis I
Math Biosci
. 2014 Dec;
260:54-64.
PMID: 25445574
In this work we explore a semi-mechanistic model that considers cortisol's permissive and suppressive effects through the regulation of cytokine receptors and cytokines respectively. Our model reveals the proactive role...
2.
Mavroudis P, Corbett S, Calvano S, Androulakis I
Physiol Genomics
. 2014 Jul;
46(20):766-78.
PMID: 25073602
In this work we propose a semimechanistic model that describes the photic signal transduction to the hypothalamic-pituitary-adrenal (HPA) axis that ultimately regulates the synchronization of peripheral clock genes (PCGs). Our...
3.
Gale S, Gao L, Mikacenic C, Coyle S, Rafaels N, Murray Dudenkov T, et al.
J Allergy Clin Immunol
. 2014 Mar;
134(1):127-34.
PMID: 24655576
Background: The genetic determinants of the human innate immune response are poorly understood. Apolipoprotein (Apo) E, a lipid-trafficking protein that affects inflammation, has well-described wild-type (ε3) and disease-associated (ε2 and...
4.
Xiao W, Mindrinos M, Seok J, Cuschieri J, Cuenca A, Gao H, et al.
J Exp Med
. 2011 Nov;
208(13):2581-90.
PMID: 22110166
Human survival from injury requires an appropriate inflammatory and immune response. We describe the circulating leukocyte transcriptome after severe trauma and burn injury, as well as in healthy subjects receiving...
5.
Scheff J, Kosmides A, Calvano S, Lowry S, Androulakis I
IEEE Trans Biomed Eng
. 2011 Jul;
58(12):3504-7.
PMID: 21775253
Glucocorticoids are steroid hormones which, among other functions, exert an antiinflammatory effect. Endogenous glucocorticoids are normally secreted by the adrenal gland in discrete bursts. It is becoming increasingly evident that...
6.
Scheff J, Mavroudis P, Calvano S, Lowry S, Androulakis I
Physiol Genomics
. 2011 Jun;
43(16):951-64.
PMID: 21673075
Heart rate variability (HRV), the quantification of beat-to-beat variability, has been studied as a potential prognostic marker in inflammatory diseases such as sepsis. HRV normally reflects significant levels of variability...
7.
Nguyen T, Foteinou P, Calvano S, Lowry S, Androulakis I
PLoS One
. 2011 Jun;
6(5):e18889.
PMID: 21637747
One of the great challenges in the post-genomic era is to decipher the underlying principles governing the dynamics of biological responses. As modulating gene expression levels is among the key...
8.
Yang Q, Calvano S, Lowry S, Androulakis I
Math Biosci
. 2011 Jun;
232(2):151-63.
PMID: 21624378
We discuss a model illustrating how the outcome of repeated endotoxin administration experiments can emerge as a natural consequence of the tightly regulated signaling pathways and also highlight the importance...
9.
Dong X, Foteinou P, Calvano S, Lowry S, Androulakis I
PLoS One
. 2010 Feb;
5(2):e9249.
PMID: 20174629
Background: Inflammation is a highly complex biological response evoked by many stimuli. A persistent challenge in modeling this dynamic process has been the (nonlinear) nature of the response that precludes...