Steven Duddy
Overview
Explore the profile of Steven Duddy including associated specialties, affiliations and a list of published articles.
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Articles
4
Citations
20
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Recent Articles
1.
Varvel N, Amaradhi R, Espinosa-Garcia C, Duddy S, Franklin R, Banik A, et al.
Neuropharmacology
. 2022 Dec;
224:109356.
PMID: 36460083
Cognitive comorbidities can substantially reduce quality of life in people with epilepsy. Inflammation is a component of all chronic diseases including epilepsy, as well as acute events like status epilepticus...
2.
Criswell K, Wojcinski Z, Pegg D, Albassam M, Duddy S, Olsen E, et al.
Toxicol Sci
. 2012 Apr;
128(1):22-41.
PMID: 22539625
In carcinogenicity studies, pregabalin increased hemangiosarcoma incidence in mice but not in rats. Investigative studies, ranging in length from 24 h to 12 months, were conducted in mice (1000 or...
3.
Pegg D, Bleavins M, Herman J, Wojcinski Z, Graziano M, Henck J, et al.
Toxicol Sci
. 2012 Apr;
128(1):9-21.
PMID: 22539615
Pregabalin, (S)-3-(aminomethyl)-5-methylhexanoic acid, binds with high affinity to the α(2)δ subunit of voltage-gated calcium channels and exerts analgesic, anxiolytic, and antiseizure activities. Two-year carcinogenicity studies were completed in B6C3F1 and...
4.
Criswell K, Cook J, Morse D, Lawton M, Somps C, Obert L, et al.
Toxicol Sci
. 2012 Apr;
128(1):42-56.
PMID: 22539613
The preceding article identified key components of pregabalin's mode of action on nongenotoxic hemangiosarcoma formation in mice, including increased serum bicarbonate leading to decreased respiratory rate, increased blood pH, increased...