David Pegg
Overview
Explore the profile of David Pegg including associated specialties, affiliations and a list of published articles.
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7
Citations
44
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Recent Articles
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Criswell K, Wojcinski Z, Pegg D, Albassam M, Duddy S, Olsen E, et al.
Toxicol Sci
. 2012 Apr;
128(1):22-41.
PMID: 22539625
In carcinogenicity studies, pregabalin increased hemangiosarcoma incidence in mice but not in rats. Investigative studies, ranging in length from 24 h to 12 months, were conducted in mice (1000 or...
3.
Criswell K, Cook J, Wojcinski Z, Pegg D, Herman J, Wesche D, et al.
Toxicol Sci
. 2012 Apr;
128(1):57-71.
PMID: 22539620
Pregabalin increased the incidence of hemangiosarcomas in carcinogenicity studies of 2-year mice but was not tumorigenic in rats. Serum bicarbonate increased within 24 h of pregabalin administration in mice and...
4.
Pegg D, Bleavins M, Herman J, Wojcinski Z, Graziano M, Henck J, et al.
Toxicol Sci
. 2012 Apr;
128(1):9-21.
PMID: 22539615
Pregabalin, (S)-3-(aminomethyl)-5-methylhexanoic acid, binds with high affinity to the α(2)δ subunit of voltage-gated calcium channels and exerts analgesic, anxiolytic, and antiseizure activities. Two-year carcinogenicity studies were completed in B6C3F1 and...
5.
Criswell K, Cook J, Morse D, Lawton M, Somps C, Obert L, et al.
Toxicol Sci
. 2012 Apr;
128(1):42-56.
PMID: 22539613
The preceding article identified key components of pregabalin's mode of action on nongenotoxic hemangiosarcoma formation in mice, including increased serum bicarbonate leading to decreased respiratory rate, increased blood pH, increased...
6.
Pegg D, Kanatas A, Makura Z
Ear Nose Throat J
. 2011 Oct;
90(10):486-8.
PMID: 22033961
We report a case of an idiopathic acquired supraglottic web in an 83-year-old man. The web was managed with a combination of dilation and unilateral CO(2) laser excision. Subsequent to...
7.
Wusteman M, Robinson M, Pegg D
Cryobiology
. 2004 Apr;
48(2):179-89.
PMID: 15094093
If large pieces of tissue and organs are to be successfully stored at low temperatures, some means must be found to minimize the disruption of extracellular structures by the ice...