Steven D Webb
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Explore the profile of Steven D Webb including associated specialties, affiliations and a list of published articles.
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36
Citations
383
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Recent Articles
1.
Pecquet A, Bridgwood K, Cowie D, Hofstra A, Wu Y, Whalley S, et al.
Crit Rev Toxicol
. 2024 Jun;
54(6):418-429.
PMID: 38869005
In the risk assessment of agrochemicals, there has been a historical paucity of using data to refine the default adjustment factors, even though large datasets are available to support this....
2.
Leedale J, Lucendo-Villarin B, Meseguer-Ripolles J, Kasarinaite A, Webb S, Hay D
PLoS One
. 2021 Feb;
16(2):e0244070.
PMID: 33556073
A major bottleneck in the study of human liver physiology is the provision of stable liver tissue in sufficient quantity. As a result, current approaches to modelling human drug efficacy...
3.
Hyndman L, McKee S, Mottram N, Singh B, Webb S, McGinty S
Interface Focus
. 2020 Mar;
10(2):20190045.
PMID: 32194930
In recent years, there has been a move away from the use of static two-dimensional cell culture models for testing the chemical safety and efficacy of drugs. Such models are...
4.
Leedale J, Kyffin J, Harding A, Colley H, Murdoch C, Sharma P, et al.
Interface Focus
. 2020 Mar;
10(2):20190041.
PMID: 32194929
In early preclinical drug development, potential candidates are tested in the laboratory using isolated cells. These experiments traditionally involve cells cultured in a two-dimensional monolayer environment. However, cells cultured in...
5.
Kelly R, Fitches M, Webb S, Pop S, Chidlow S
Theor Biol Med Model
. 2019 Dec;
16(1):21.
PMID: 31829209
Background: Glucose tolerance testing is a tool used to estimate glucose effectiveness and insulin sensitivity in diabetic patients. The importance of such tests has prompted the development and utilisation of...
6.
Kyffin J, Cox C, Leedale J, Colley H, Murdoch C, Mistry P, et al.
Curr Protoc Toxicol
. 2019 Sep;
81(1):e87.
PMID: 31529797
Herein, we describe a protocol for the preparation and analysis of primary isolated rat hepatocytes in a 3D cell culture format described as spheroids. The hepatocyte cells spontaneously self-aggregate into...
7.
Thaventhiran T, Wong W, Alghanem A, Alhumeed N, Aljasir M, Ramsey S, et al.
Monoclon Antib Immunodiagn Immunother
. 2019 Apr;
38(2):60-69.
PMID: 31009338
CD28 superagonist (CD28SA), a therapeutic immunomodulatory monoclonal antibody triggered rapid and exaggerated activation of CD4 effector memory T cells (T) in humans with unwanted serious adverse effects. It is well...
8.
Tomlinson L, Hyndman L, Firman J, Bentley R, Kyffin J, Webb S, et al.
Front Bioeng Biotechnol
. 2019 Mar;
7:17.
PMID: 30834246
The ability of the liver to simultaneously carry out multiple functions is dependent on the metabolic heterogeneity of hepatocytes spatially located within a liver lobule spanning from the portal triad...
9.
Tomlinson L, Lu Z, Bentley R, Colley H, Murdoch C, Webb S, et al.
Biomed Pharmacother
. 2019 Feb;
112:108637.
PMID: 30798127
Dose-dependent cardiotoxicity is the leading adverse reaction seen in cancer patients treated with doxorubicin. Currently, dexrazoxane is the only approved drug that can partially protect against this toxicity in patients,...
10.
Kyffin J, Sharma P, Leedale J, Colley H, Murdoch C, Harding A, et al.
Toxicol In Vitro
. 2018 Dec;
55:160-172.
PMID: 30578835
Many in vitro liver cell models, such as 2D systems, that are used to assess the hepatotoxic potential of xenobiotics suffer major limitations arising from a lack of preservation of...