Steven D Webb
Overview
Explore the profile of Steven D Webb including associated specialties, affiliations and a list of published articles.
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36
Citations
383
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Recent Articles
11.
Kelly R, Leedale J, Harrell A, Beard D, Randle L, Chadwick A, et al.
PLoS One
. 2018 Nov;
13(11):e0207803.
PMID: 30496306
Cancer cells depend on glucose metabolism via glycolysis as a primary energy source, despite the presence of oxygen and fully functioning mitochondria, in order to promote growth, proliferation and longevity....
12.
Pletz J, Enoch S, Jais D, Mellor C, Pawar G, Firman J, et al.
Expert Opin Drug Metab Toxicol
. 2018 Oct;
14(12):1225-1253.
PMID: 30345815
The kidney is a major target for toxicity elicited by pharmaceuticals and environmental pollutants. Standard testing which often does not investigate underlying mechanisms has proven not to be an adequate...
13.
Leedale J, Sharkey K, Colley H, Norton A, Peeney D, Mason C, et al.
iScience
. 2018 Sep;
4:84-96.
PMID: 30240756
Many xenobiotics can bind to off-target receptors and cause toxicity via the dysregulation of downstream transcription factors. Identification of subsequent off-target toxicity in these chemicals has often required extensive chemical...
14.
Mason C, Leedale J, Tasoulis S, Jarman I, Antoine D, Webb S
CPT Pharmacometrics Syst Pharmacol
. 2018 Apr;
7(6):394-403.
PMID: 29667370
Paracetamol (acetaminophen (APAP)) is one of the most commonly used analgesics in the United Kingdom and the United States. However, exceeding the maximum recommended dose can cause serious liver injury...
15.
Kyffin J, Sharma P, Leedale J, Colley H, Murdoch C, Mistry P, et al.
Toxicol In Vitro
. 2018 Feb;
48:262-275.
PMID: 29408671
Xenobiotic safety assessment is an area that impacts a multitude of different industry sectors such as medicinal drugs, agrochemicals, industrial chemicals, cosmetics and environmental contaminants. As such there are a...
16.
Smith S, Colley H, Sharma P, Slowik K, Sison-Young R, Sneddon A, et al.
Exp Dermatol
. 2017 Dec;
27(5):473-475.
PMID: 29227563
CYP3A4 and CYP4A5 share specificity for a wide range of xenobiotics with the CYP3 subfamily collectively involved in the biotransformation of approximately 30% of all drugs. CYP3A4/5 mRNA transcripts have...
17.
Gaskell H, Sharma P, Colley H, Murdoch C, Williams D, Webb S
Toxicol Res (Camb)
. 2016 Oct;
5(4):1053-1065.
PMID: 27746894
More predictive liver models are a critical requirement for preclinical screening of compounds demonstrating hepatotoxic liability. 3D liver spheroids have been shown to have an enhanced functional lifespan compared to...
18.
Thaventhiran T, Alhumeed N, Yeang H, Sethu S, Downey J, Alghanem A, et al.
MAbs
. 2014 Dec;
6(5):1290-9.
PMID: 25517314
The CD28 superagonist (CD28SA) TGN1412 was administered to humans as an agent that can selectively activate and expand regulatory T cells but resulted in uncontrolled T cell activation accompanied by...
19.
Sorrell I, Shipley R, Hearnden V, Colley H, Thornhill M, Murdoch C, et al.
Nanomedicine
. 2013 Sep;
10(2):339-48.
PMID: 24036098
From The Clinical Editor: This article reports on a validated model developed through a combination of in vitro experimentation and mathematical modeling of nanoparticle uptake by cells via the clathrin-mediated...
20.
Al-Husari M, Webb S
PLoS One
. 2013 Aug;
8(8):e72020.
PMID: 23991029
High levels of lactate and H(+)-ions play an important role in the invasive and metastatic cascade of some tumours. We develop a mathematical model of cellular pH regulation focusing on...