Steven D Horne
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Explore the profile of Steven D Horne including associated specialties, affiliations and a list of published articles.
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14
Citations
370
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Recent Articles
1.
Heng H, Horne S, Chaudhry S, Regan S, Liu G, Abdallah B, et al.
Curr Genomics
. 2018 Apr;
19(3):227-239.
PMID: 29606910
Background: The postgenomic era is featured by massive data collection and analyses from various large scale-omics studies. Despite the promising capability of systems biology and bioinformatics to handle large data...
2.
Liu G, Ye C, Chowdhury S, Abdallah B, Horne S, Nichols D, et al.
Curr Genomics
. 2018 Apr;
19(3):200-206.
PMID: 29606907
Background: Gulf War Illness (GWI) impacts 25-30% of gulf war veterans. Due to its heterogeneity in both etiology and symptoms, it has been challenging to establish the commonly accepted case...
3.
Horne S, Pollick S, Heng H
Int J Cancer
. 2014 Jun;
136(9):2012-21.
PMID: 24957955
The basis for the gene mutation theory of cancer that dominates current molecular cancer research consists of: the belief that gene-level aberrations such as mutations are the main cause of...
4.
Horne S, Chowdhury S, Heng H
Front Genet
. 2014 May;
5:92.
PMID: 24795754
Cells are constantly exposed to various internal and external stresses. The importance of cellular stress and its implication to disease conditions have become popular research topics. Many ongoing investigations focus...
5.
Liu G, Stevens J, Horne S, Abdallah B, Ye K, Bremer S, et al.
Cell Cycle
. 2013 Dec;
13(4):528-37.
PMID: 24299711
Genome chaos, a process of complex, rapid genome re-organization, results in the formation of chaotic genomes, which is followed by the potential to establish stable genomes. It was initially detected...
6.
Abdallah B, Horne S, Kurkinen M, Stevens J, Liu G, Ye C, et al.
Syst Biol Reprod Med
. 2013 Oct;
60(1):2-13.
PMID: 24147962
Ovarian cancer is the fifth leading cause of death among women worldwide. Characterized by complex etiology and multi-level heterogeneity, its origins are not well understood. Intense research efforts over the...
7.
Stevens J, Liu G, Abdallah B, Horne S, Ye K, Bremer S, et al.
Int J Cancer
. 2013 Oct;
134(9):2074-87.
PMID: 24122714
The challenge of identifying common expression signatures in cancer is well known, however the reason behind this is largely unclear. Traditionally variation in expression signatures has been attributed to technological...
8.
Abdallah B, Horne S, Stevens J, Liu G, Ying A, Vanderhyden B, et al.
Cell Cycle
. 2013 Oct;
12(23):3640-9.
PMID: 24091732
Multi-level heterogeneity is a fundamental but underappreciated feature of cancer. Most technical and analytical methods either completely ignore heterogeneity or do not fully account for it, as heterogeneity has been...
9.
Heng H, Bremer S, Stevens J, Horne S, Liu G, Abdallah B, et al.
Cancer Metastasis Rev
. 2013 Apr;
32(3-4):325-40.
PMID: 23605440
Results of various cancer genome sequencing projects have "unexpectedly" challenged the framework of the current somatic gene mutation theory of cancer. The prevalence of diverse genetic heterogeneity observed in cancer...
10.
Stevens J, Horne S, Abdallah B, Ye C, Heng H
Cancer Metastasis Rev
. 2013 Apr;
32(3-4):391-402.
PMID: 23595307
Whole transcriptome profiling has long been proposed as a method of identifying cancer-specific gene expression profiles. Indeed, a multitude of these studies have generated vast amounts of expression data for...