Steven B Wells
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Explore the profile of Steven B Wells including associated specialties, affiliations and a list of published articles.
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13
Citations
731
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Recent Articles
1.
Caron D, Specht W, Chen D, Wells S, Szabo P, Jensen I, et al.
Cell Rep Methods
. 2025 Jan;
5(1):100938.
PMID: 39814026
Single-cell RNA sequencing (scRNA-seq) is invaluable for profiling cellular heterogeneity and transcriptional states, but transcriptomic profiles do not always delineate subsets defined by surface proteins. Cellular indexing of transcriptomes and...
2.
Davis-Porada J, George A, Lam N, Caron D, Gray J, Huang J, et al.
Immunity
. 2024 Nov;
57(12):2895-2913.e8.
PMID: 39510068
Memory T and B cells in tissues are essential for protective immunity. Here, we performed a comprehensive analysis of the tissue distribution, phenotype, durability, and transcriptional profile of COVID-19 mRNA...
3.
Gray J, Caron D, Wells S, Guyer R, Szabo P, Rainbow D, et al.
Sci Immunol
. 2024 Jun;
9(96):eadn3954.
PMID: 38848342
During ontogeny, γδ T cells emerge from the thymus and directly seed peripheral tissues for in situ immunity. However, their functional role in humans has largely been defined from blood....
4.
Wells S, Rainbow D, Mark M, Szabo P, Ergen C, Maceiras A, et al.
bioRxiv
. 2024 Jan;
PMID: 38260588
The immune system comprises multiple cell lineages and heterogeneous subsets found in blood and tissues throughout the body. While human immune responses differ between sites and over age, the underlying...
5.
Caron D, Specht W, Chen D, Wells S, Szabo P, Jensen I, et al.
bioRxiv
. 2023 Jul;
PMID: 37461466
Single-cell RNA sequencing (scRNA-seq) is invaluable for profiling cellular heterogeneity and dissecting transcriptional states, but transcriptomic profiles do not always delineate subsets defined by surface proteins, as in cells of...
6.
Poon M, Caron D, Wang Z, Wells S, Chen D, Meng W, et al.
Nat Immunol
. 2023 Jan;
24(2):309-319.
PMID: 36658238
T lymphocytes migrate to barrier sites after exposure to pathogens, providing localized immunity and long-term protection. Here, we obtained blood and tissues from human organ donors to examine T cells...
7.
Ural B, Caron D, Dogra P, Wells S, Szabo P, Granot T, et al.
Nat Med
. 2022 Nov;
28(12):2622-2632.
PMID: 36411343
Older people are particularly susceptible to infectious and neoplastic diseases of the lung and it is unclear how lifelong exposure to environmental pollutants affects respiratory immune function. In an analysis...
8.
Chait M, Yilmaz M, Shakil S, Ku A, Dogra P, Connors T, et al.
JCI Insight
. 2022 Apr;
7(11).
PMID: 35446789
Respiratory failure in COVID-19 is characterized by widespread disruption of the lung's alveolar gas exchange interface. To elucidate determinants of alveolar lung damage, we performed epithelial and immune cell profiling...
9.
Poon M, Byington E, Meng W, Kubota M, Matsumoto R, Grifoni A, et al.
Cell Rep
. 2021 Dec;
37(9):110071.
PMID: 34852222
The persistence of anti-viral immunity is essential for protection and exhibits profound heterogeneity across individuals. Here, we elucidate the factors that shape maintenance and function of anti-viral T cell immunity...
10.
Poon M, Rybkina K, Kato Y, Kubota M, Matsumoto R, Bloom N, et al.
Sci Immunol
. 2021 Oct;
6(65):eabl9105.
PMID: 34618554
Adaptive immune responses to SARS-CoV-2 infection have been extensively characterized in blood; however, most functions of protective immunity must be accomplished in tissues. Here, we report from examination of SARS-CoV-2...