Steven Alvarez
Overview
Explore the profile of Steven Alvarez including associated specialties, affiliations and a list of published articles.
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14
Citations
372
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Recent Articles
1.
Lee A, Kim N, Alvarez S, Ren H, DeGrandchamp J, Lew L, et al.
Sci Adv
. 2024 Jun;
10(25):eadi0707.
PMID: 38905351
Ras is a small GTPase that is central to important functional decisions in diverse cell types. An important aspect of Ras signaling is its ability to exhibit bimodal or switch-like...
2.
Lee A, Kim N, Alvarez S, Ren H, DeGrandchamp J, Lew L, et al.
bioRxiv
. 2023 Jul;
PMID: 37503094
Ras is a small GTPase that is central to important functional decisions in diverse cell types. An important aspect of Ras signaling is its ability to exhibit bimodal, or switch-like...
3.
Lin C, Nocka L, Stinger B, DeGrandchamp J, Lew L, Alvarez S, et al.
Proc Natl Acad Sci U S A
. 2022 May;
119(19):e2122531119.
PMID: 35507881
We reconstitute a phosphotyrosine-mediated protein condensation phase transition of the ∼200 residue cytoplasmic tail of the epidermal growth factor receptor (EGFR) and the adaptor protein, Grb2, on a membrane surface....
4.
Lee A, Huang W, Hansen S, Kim N, Alvarez S, Groves J
Proc Natl Acad Sci U S A
. 2021 Nov;
118(47).
PMID: 34789575
Here, we present detailed kinetic analyses of a panel of soluble lipid kinases and phosphatases, as well as Ras activating proteins, acting on their respective membrane surface substrates. The results...
5.
Huang W, Alvarez S, Kondo Y, Kuriyan J, Groves J
Proc Natl Acad Sci U S A
. 2021 Nov;
118(45).
PMID: 34740968
Son of Sevenless (SOS) is a Ras guanine nucleotide exchange factor (GEF) that plays a central role in numerous cellular signaling pathways. Like many other signaling molecules, SOS is autoinhibited...
6.
Packer M, Parker J, Chung J, Li Z, Lee Y, Cookis T, et al.
Proc Natl Acad Sci U S A
. 2021 Mar;
118(10).
PMID: 33653954
Ras dimerization is critical for Raf activation. Here we show that the Ras binding domain of Raf (Raf-RBD) induces robust Ras dimerization at low surface densities on supported lipid bilayers...
7.
Chen Z, Cao Y, Lin C, Alvarez S, Oh D, Yang P, et al.
Proc Natl Acad Sci U S A
. 2021 Jan;
118(5).
PMID: 33495347
Multicolor single-molecule tracking (SMT) provides a powerful tool to mechanistically probe molecular interactions in living cells. However, because of the limitations in the optical and chemical properties of currently available...
8.
Huang W, Alvarez S, Kondo Y, Lee Y, Chung J, Lam H, et al.
Science
. 2019 Mar;
363(6431):1098-1103.
PMID: 30846600
The guanine nucleotide exchange factor (GEF) Son of Sevenless (SOS) is a key Ras activator that is autoinhibited in the cytosol and activates upon membrane recruitment. Autoinhibition release involves structural...
9.
K-Ras4B Remains Monomeric on Membranes over a Wide Range of Surface Densities and Lipid Compositions
Chung J, Lee Y, Denson J, Gillette W, Alvarez S, Stephen A, et al.
Biophys J
. 2018 Jan;
114(1):137-145.
PMID: 29320680
Ras is a membrane-anchored signaling protein that serves as a hub for many signaling pathways and also plays a prominent role in cancer. The intrinsic behavior of Ras on the...
10.
Lee Y, Low-Nam S, Chung J, Hansen S, Lam H, Alvarez S, et al.
Nat Commun
. 2017 Apr;
8:15061.
PMID: 28452363
The guanine nucleotide exchange factor (GEF) Son of Sevenless (SOS) plays a critical role in signal transduction by activating Ras. Here we introduce a single-molecule assay in which individual SOS...