Joseph B DeGrandchamp
Overview
Explore the profile of Joseph B DeGrandchamp including associated specialties, affiliations and a list of published articles.
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5
Citations
42
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Recent Articles
1.
Ren H, Lee A, Lew L, DeGrandchamp J, Groves J
Biophys J
. 2024 Jul;
123(19):3295-3303.
PMID: 39021073
Signaling through the Ras-MAPK pathway can exhibit switch-like activation, which has been attributed to the underlying positive feedback and bimodality in the activation of RasGDP to RasGTP by SOS. SOS...
2.
Lee A, Kim N, Alvarez S, Ren H, DeGrandchamp J, Lew L, et al.
Sci Adv
. 2024 Jun;
10(25):eadi0707.
PMID: 38905351
Ras is a small GTPase that is central to important functional decisions in diverse cell types. An important aspect of Ras signaling is its ability to exhibit bimodal or switch-like...
3.
Lee A, Kim N, Alvarez S, Ren H, DeGrandchamp J, Lew L, et al.
bioRxiv
. 2023 Jul;
PMID: 37503094
Ras is a small GTPase that is central to important functional decisions in diverse cell types. An important aspect of Ras signaling is its ability to exhibit bimodal, or switch-like...
4.
Lin C, Nocka L, Stinger B, DeGrandchamp J, Lew L, Alvarez S, et al.
Proc Natl Acad Sci U S A
. 2022 May;
119(19):e2122531119.
PMID: 35507881
We reconstitute a phosphotyrosine-mediated protein condensation phase transition of the ∼200 residue cytoplasmic tail of the epidermal growth factor receptor (EGFR) and the adaptor protein, Grb2, on a membrane surface....
5.
Xia Z, DeGrandchamp J, Williams E
Analyst
. 2019 Mar;
144(8):2565-2573.
PMID: 30882808
Native mass spectrometry is widely used to probe the structures, stabilities, and stoichiometries of proteins and biomolecular complexes in aqueous solutions, typically containing volatile ammonium acetate or ammonium bicarbonate buffer....