Steve Stippec
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Explore the profile of Steve Stippec including associated specialties, affiliations and a list of published articles.
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24
Citations
724
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Recent Articles
1.
Taylor C, Jung J, Gallolu Kankanamalage S, Li J, Grzemska M, Jaykumar A, et al.
bioRxiv
. 2024 Jul;
PMID: 38979344
The WNK-OSR1/SPAK protein kinase signaling pathway regulates ion homeostasis and cell volume, but its other functions are poorly understood. To uncover undefined signaling functions of the pathway we analyzed the...
2.
Delgado M, Gallegos Z, Stippec S, McGlynn K, Cobb M, Whitehurst A
J Biol Chem
. 2024 May;
300(6):107380.
PMID: 38762178
Cancer testis antigens (CTAs) are a collection of proteins whose expression is normally restricted to the gamete but abnormally activated in a wide variety of tumors. The CTA, Testis-specific serine...
3.
Delgado M, Gallegos Z, McGlynn K, Stippec S, Cobb M, Whitehurst A
bioRxiv
. 2024 Jan;
PMID: 38260312
Cancer testis antigens (CTAs) are a collection of proteins whose expression is normally restricted to the gamete, but abnormally activated in a wide variety of tumors. The CTA, Testis specific...
4.
Barylko B, Taylor 4th C, Wang J, Earnest S, Stippec S, Binns D, et al.
Int J Mol Sci
. 2024 Jan;
25(2).
PMID: 38255853
Activity-regulated cytoskeleton-associated protein (Arc) plays essential roles in diverse forms of synaptic plasticity, including long-term potentiation (LTP), long-term depression (LTD), and homeostatic plasticity. In addition, it assembles into virus-like particles...
5.
Taylor 4th C, Cormier K, Martin-Vega A, Earnest S, Stippec S, Wichaidit C, et al.
Biochemistry
. 2023 Apr;
62(9):1433-1442.
PMID: 37021821
The most frequent ERK2 (MAPK1) mutation in cancers, E322K, lies in the common docking (CD) site, which binds short motifs made up of basic and hydrophobic residues present in the...
6.
Taylor 4th C, Cormier K, Keenan S, Earnest S, Stippec S, Wichaidit C, et al.
Proc Natl Acad Sci U S A
. 2019 Jul;
116(31):15514-15523.
PMID: 31296562
The most frequent extracellular signal-regulated kinase 2 (ERK2) mutation occurring in cancers is E322K (E-K). ERK2 E-K reverses a buried charge in the ERK2 common docking (CD) site, a region...
7.
Taylor 4th C, An S, Gallolu Kankanamalage S, Stippec S, Earnest S, Trivedi A, et al.
Proc Natl Acad Sci U S A
. 2018 Mar;
115(15):3840-3845.
PMID: 29581290
The with-no-lysine (K) (WNK) signaling pathway to STE20/SPS1-related proline- and alanine-rich kinase (SPAK) and oxidative stress-responsive 1 (OSR1) kinase is an important mediator of cell volume and ion transport. SPAK...
8.
Karra A, Stippec S, Cobb M
J Vis Exp
. 2017 Jun;
(123).
PMID: 28605363
Protein kinases are able to govern large-scale cellular changes in response to complex arrays of stimuli, and much effort has been directed at uncovering allosteric details of their regulation. Kinases...
9.
Gallolu Kankanamalage S, Lee A, Wichaidit C, Lorente-Rodriguez A, Shah A, Stippec S, et al.
Autophagy
. 2017 Mar;
13(5):969-970.
PMID: 28282258
Autophagy is a cellular degradation pathway that is essential to maintain cellular physiology, and deregulation of autophagy leads to multiple diseases in humans. In a recent study, we discovered that...
10.
Gallolu Kankanamalage S, Lee A, Wichaidit C, Lorente-Rodriguez A, Shah A, Stippec S, et al.
Proc Natl Acad Sci U S A
. 2016 Dec;
113(50):14342-14347.
PMID: 27911840
The with-no-lysine (K) (WNK) kinases are an atypical family of protein kinases that regulate ion transport across cell membranes. Mutations that result in their overexpression cause hypertension-related disorders in humans....