Steve Stegen
Overview
Explore the profile of Steve Stegen including associated specialties, affiliations and a list of published articles.
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Articles
29
Citations
1244
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0
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Recent Articles
1.
Sommers V, David K, Helsen C, Moermans K, Stockmans I, Ferrari G, et al.
J Endocrinol
. 2025 Jan;
264(3).
PMID: 39831834
Glucocorticoids and androgens affect each other in several ways. In metabolic organs, such as adipose tissue and the liver, androgens enhance glucocorticoid-induced insulin resistance and promote fat accumulation in male...
2.
Loopmans S, Rohlenova K, Van Brussel T, Stockmans I, Moermans K, Peredo N, et al.
Nat Metab
. 2025 Jan;
7(1):182-195.
PMID: 39794539
Bone lengthening and fracture repair depend on the anabolic properties of chondrocytes that function in an avascular milieu. The limited supply of oxygen and nutrients calls into question how biosynthesis...
3.
Stegen S, Carmeliet G
Nat Rev Endocrinol
. 2024 Mar;
20(7):399-413.
PMID: 38499689
Bone development and bone remodelling during adult life are highly anabolic processes requiring an adequate supply of oxygen and nutrients. Bone-forming osteoblasts and bone-resorbing osteoclasts interact closely to preserve bone...
4.
Loopmans S, Tournaire G, Stockmans I, Stegen S, Carmeliet G
J Bone Miner Res
. 2024 Mar;
39(2):150-160.
PMID: 38477776
Skeletal stem and progenitor cells (SSPCs) are crucial for bone development, homeostasis, and repair. SSPCs are considered to reside in a rather hypoxic niche in the bone, but distinct SSPC...
5.
Stegen S, Moermans K, Stockmans I, Thienpont B, Carmeliet G
Nat Metab
. 2024 Jan;
6(1):141-152.
PMID: 38200114
Bone-resorbing osteoclasts are vital for postnatal bone health, as increased differentiation or activity results in skeletal pathologies such as osteoporosis. The metabolism of mature osteoclasts differs from their progenitor cells,...
6.
van der Eerden B, Riddle R, Stegen S, Tencerova M
Front Physiol
. 2023 Jun;
14:1205435.
PMID: 37284545
No abstract available.
7.
Noonan M, Ni P, Solis E, Marambio Y, Agoro R, Chu X, et al.
Bone Res
. 2023 Jan;
11(1):7.
PMID: 36650133
Osteocytes act within a hypoxic environment to control key steps in bone formation. FGF23, a critical phosphate-regulating hormone, is stimulated by low oxygen/iron in acute and chronic diseases, however the...
8.
Devignes C, Carmeliet G, Stegen S
Bone Rep
. 2022 Sep;
17:101620.
PMID: 36120644
Amino acid metabolism regulates essential cellular functions, not only by fueling protein synthesis, but also by supporting the biogenesis of nucleotides, redox factors and lipids. Amino acids are also involved...
9.
Loopmans S, Stockmans I, Carmeliet G, Stegen S
Front Endocrinol (Lausanne)
. 2022 Aug;
13:930358.
PMID: 35979436
Skeletal stem and progenitor cells (SSPCs) constitute a reservoir of bone-forming cells necessary for bone development, modeling and remodeling, as well as for fracture healing. Recent advances in tools to...
10.
Tournaire G, Loopmans S, Stegen S, Rinaldi G, Eelen G, Torrekens S, et al.
Cell Rep
. 2022 Jul;
40(4):111105.
PMID: 35905715
A functional electron transport chain (ETC) is crucial for supporting bioenergetics and biosynthesis. Accordingly, ETC inhibition decreases proliferation in cancer cells but does not seem to impair stem cell proliferation....