Steve Schoonooghe
Overview
Explore the profile of Steve Schoonooghe including associated specialties, affiliations and a list of published articles.
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33
Citations
1067
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Recent Articles
1.
Stijlemans B, De Baetselier P, Van Molle I, Lecordier L, Hendrickx E, Romao E, et al.
Nat Commun
. 2024 Feb;
15(1):1779.
PMID: 38413606
Human African trypanosomiasis or sleeping sickness, caused by the protozoan parasite Trypanosoma brucei, is characterized by the manipulation of the host's immune response to ensure parasite invasion and persistence. Uncovering...
2.
Hart J, Liu X, Pan C, Liang A, Ueno L, Xu Y, et al.
Proc Natl Acad Sci U S A
. 2022 Sep;
119(38):e2210769119.
PMID: 36095215
Nanobodies and chemical cross-linking were used to gain information on the identity and positions of flexible domains of PI3Kα. The application of chemical cross-linking mass spectrometry (CXMS) facilitated the identification...
3.
Gevenois P, De Pauw P, Schoonooghe S, Delporte C, Sebti T, Amighi K, et al.
J Immunol
. 2021 Oct;
207(10):2608-2620.
PMID: 34645688
IL-13 is a pleiotropic cytokine mainly secreted by Th2 cells. It reacts with many different types of cells involved in allergy, inflammation, and fibrosis, e.g., mastocytes, B cells, and fibroblasts....
4.
Zheng F, Zhou J, Ouyang Z, Zhang J, Wang X, Muyldermans S, et al.
Front Immunol
. 2021 Mar;
12:641819.
PMID: 33692811
Nanobodies that are derived from single-chain antibodies of camelids have served as powerful tools in diagnostics, therapeutics and investigation of membrane receptors' structure and function. In this study, we developed...
5.
De Vlaeminck Y, Bonelli S, Awad R, Dewilde M, Rizzolio S, Lecocq Q, et al.
Cancers (Basel)
. 2020 Dec;
12(12).
PMID: 33266104
Neuropilin-1 (NRP-1) is a co-receptor for semaphorins and vascular endothelial growth factor (VEGF) family members that can be expressed on cancer cells and tumor-infiltrating myeloid, endothelial and lymphoid cells. It...
6.
Zheng F, Luo S, Ouyang Z, Zhou J, Mo H, Schoonooghe S, et al.
Int J Mol Sci
. 2019 Jul;
20(13).
PMID: 31288389
Nanobody against V-set and Ig domain-containing 4 (Vsig4) on tissue macrophages, such as synovial macrophages, could visualize joint inflammation in multiple experimental arthritis models via single-photon emission computed tomography imaging....
7.
Evaluating a Single Domain Antibody Targeting Human PD-L1 as a Nuclear Imaging and Therapeutic Agent
Broos K, Lecocq Q, Xavier C, Bridoux J, Nguyen T, Corthals J, et al.
Cancers (Basel)
. 2019 Jun;
11(6).
PMID: 31234464
The PD-1:PD-L1 immune checkpoint axis is central in the escape of cancer cells from anticancer immune responses. Monoclonal antibodies (mAbs) specific for PD-L1 have been approved for treatment of various...
8.
De Vlaeminck Y, Lecocq Q, Giron P, Heirman C, Geeraerts X, Bolli E, et al.
J Control Release
. 2019 Feb;
299:107-120.
PMID: 30797866
The tumor microenvironment of numerous prevalent cancer types is abundantly infiltrated with tumor-associated macrophages (TAMs). Macrophage mannose receptor (MMR or CD206) expressing TAMs have been shown to be key promoters...
9.
Sparkes A, De Baetselier P, Brys L, Cabrito I, Sterckx Y, Schoonooghe S, et al.
FASEB J
. 2018 Feb;
32(6):3411-3422.
PMID: 29401625
Sepsis-leading to septic shock-is the leading cause of death in intensive care units. The systemic inflammatory response to infection, which is initiated by activated myeloid cells, plays a key role...
10.
Van den Hoecke S, Ehrhardt K, Kolpe A, Bakkouri K, Deng L, Grootaert H, et al.
J Virol
. 2017 Jan;
91(7).
PMID: 28077656
The ectodomain of matrix protein 2 is a universal influenza A virus vaccine candidate that provides protection through antibody-dependent effector mechanisms. Here we compared the functional engagement of Fcγ receptor...