Steve Goldstein
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Explore the profile of Steve Goldstein including associated specialties, affiliations and a list of published articles.
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21
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1220
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Recent Articles
11.
Bradnam K, Fass J, Alexandrov A, Baranay P, Bechner M, Birol I, et al.
Gigascience
. 2013 Jul;
2(1):10.
PMID: 23870653
Background: The process of generating raw genome sequence data continues to become cheaper, faster, and more accurate. However, assembly of such data into high-quality, finished genome sequences remains challenging. Many...
12.
van Heesch S, Kloosterman W, Lansu N, Ruzius F, Levandowsky E, Lee C, et al.
BMC Genomics
. 2013 Apr;
14:257.
PMID: 23590730
Background: Paired-tag sequencing approaches are commonly used for the analysis of genome structure. However, mammalian genomes have a complex organization with a variety of repetitive elements that complicate comprehensive genome-wide...
13.
McGaugh S, Heil C, Manzano-Winkler B, Loewe L, Goldstein S, Himmel T, et al.
PLoS Biol
. 2012 Nov;
10(11):e1001422.
PMID: 23152720
One of the most influential observations in molecular evolution has been a strong association between local recombination rate and nucleotide polymorphisms across the genome. This is interpreted as evidence for...
14.
Lin H, Goldstein S, Mendelowitz L, Zhou S, Wetzel J, Schwartz D, et al.
BMC Bioinformatics
. 2012 Aug;
13:189.
PMID: 22856673
Background: Genome assembly is difficult due to repeated sequences within the genome, which create ambiguities and cause the final assembly to be broken up into many separate sequences (contigs). Long...
15.
Sarkar D, Goldstein S, Schwartz D, Newton M
J Comput Biol
. 2012 Apr;
19(5):478-92.
PMID: 22506568
The Optical Mapping System constructs ordered restriction maps spanning entire genomes through the assembly and analysis of large datasets comprising individually analyzed genomic DNA molecules. Such restriction maps uniquely reveal...
16.
Zhou S, Wei F, Nguyen J, Bechner M, Potamousis K, Goldstein S, et al.
PLoS Genet
. 2009 Nov;
5(11):e1000711.
PMID: 19936062
About 85% of the maize genome consists of highly repetitive sequences that are interspersed by low-copy, gene-coding sequences. The maize community has dealt with this genomic complexity by the construction...
17.
Church D, Goodstadt L, Hillier L, Zody M, Goldstein S, She X, et al.
PLoS Biol
. 2009 May;
7(5):e1000112.
PMID: 19468303
The mouse (Mus musculus) is the premier animal model for understanding human disease and development. Here we show that a comprehensive understanding of mouse biology is only possible with the...
18.
Ananiev G, Goldstein S, Runnheim R, Forrest D, Zhou S, Potamousis K, et al.
BMC Mol Biol
. 2008 Aug;
9:68.
PMID: 18667073
Background: Methylation of CpG dinucleotides is a fundamental mechanism of epigenetic regulation in eukaryotic genomes. Development of methods for rapid genome wide methylation profiling will greatly facilitate both hypothesis and...
19.
Zhou S, Bechner M, Place M, Churas C, Pape L, Leong S, et al.
BMC Genomics
. 2007 Aug;
8:278.
PMID: 17697381
Background: Rice feeds much of the world, and possesses the simplest genome analyzed to date within the grass family, making it an economically relevant model system for other cereal crops....
20.
Reslewic S, Zhou S, Place M, Zhang Y, Briska A, Goldstein S, et al.
Appl Environ Microbiol
. 2005 Sep;
71(9):5511-22.
PMID: 16151144
Rhodospirillum rubrum is a phototrophic purple nonsulfur bacterium known for its unique and well-studied nitrogen fixation and carbon monoxide oxidation systems and as a source of hydrogen and biodegradable plastic...