Stephen Willingham
Overview
Explore the profile of Stephen Willingham including associated specialties, affiliations and a list of published articles.
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Articles
5
Citations
761
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0
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Recent Articles
1.
Upton R, Banuelos A, Feng D, Biswas T, Kao K, McKenna K, et al.
Proc Natl Acad Sci U S A
. 2021 Jul;
118(29).
PMID: 34257155
Trastuzumab, a targeted anti-human epidermal-growth-factor receptor-2 (HER2) monoclonal antibody, represents a mainstay in the treatment of HER2-positive (HER2) breast cancer. Although trastuzumab treatment is highly efficacious for early-stage HER2 breast...
2.
Gholamin S, Mitra S, Feroze A, Liu J, Kahn S, Zhang M, et al.
Sci Transl Med
. 2017 Mar;
9(381).
PMID: 28298418
Morbidity and mortality associated with pediatric malignant primary brain tumors remain high in the absence of effective therapies. Macrophage-mediated phagocytosis of tumor cells via blockade of the anti-phagocytic CD47-SIRPα interaction...
3.
Liu J, Wang L, Zhao F, Tseng S, Narayanan C, Shura L, et al.
PLoS One
. 2015 Sep;
10(9):e0137345.
PMID: 26390038
CD47 is a widely expressed cell surface protein that functions as a regulator of phagocytosis mediated by cells of the innate immune system, such as macrophages and dendritic cells. CD47...
4.
Edris B, Willingham S, Weiskopf K, Volkmer A, Volkmer J, Muhlenberg T, et al.
Oncoimmunology
. 2013 Jul;
2(6):e24452.
PMID: 23894705
Acquired resistance to imatinib is a significant problem for the clinical management of gastrointestinal stromal tumor (GIST) patients, and second-line small molecules have shown limited efficacy in this setting. We...
5.
Willingham S, Outeiro T, DeVit M, Lindquist S, Muchowski P
Science
. 2003 Dec;
302(5651):1769-72.
PMID: 14657499
Genome-wide screens were performed in yeast to identify genes that enhance the toxicity of a mutant huntingtin fragment or of alpha-synuclein. Of 4850 haploid mutants containing deletions of nonessential genes,...