Stephen W Edwards
Overview
Explore the profile of Stephen W Edwards including associated specialties, affiliations and a list of published articles.
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46
Citations
921
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Recent Articles
1.
Nelms M, Antonijevic T, Ring C, Harris D, Bever R, Lynn S, et al.
Front Toxicol
. 2024 May;
6:1346767.
PMID: 38694816
Introduction: The U. S. Environmental Protection Agency's Endocrine Disruptor Screening Program (EDSP) Tier 1 assays are used to screen for potential endocrine system-disrupting chemicals. A model integrating data from 16...
2.
Bever R, Edwards S, Antonijevic T, Nelms M, Ring C, Harris D, et al.
Front Toxicol
. 2024 Mar;
6:1347364.
PMID: 38529103
Computational models using data from high-throughput screening assays have promise for prioritizing and screening chemicals for testing under the U.S. Environmental Protection Agency's Endocrine Disruptor Screening Program (EDSP). The purpose...
3.
Nelms M, Mellor C, Enoch S, Judson R, Patlewicz G, Richard A, et al.
Comput Toxicol
. 2023 Feb;
8:1-12.
PMID: 36779220
Adverse Outcome Pathways (AOPs) establish a connection between a molecular initiating event (MIE) and an adverse outcome. Detailed understanding of the MIE provides the ideal data for determining chemical properties...
4.
Ives C, Pan H, Edwards S, Nelms M, Covert H, Lichtveld M, et al.
J Expo Sci Environ Epidemiol
. 2022 Mar;
33(1):12-16.
PMID: 35347232
The disparate measurement protocols used to collect study data are an intrinsic barrier to combining information from environmental health studies. Using standardized measurement protocols and data standards for environmental exposures...
5.
Edwards S, Nelms M, Hench V, Ponder J, Sullivan K
Front Toxicol
. 2022 Mar;
4:824094.
PMID: 35295211
Regulatory agencies around the world have committed to reducing or eliminating animal testing for establishing chemical safety. Adverse outcome pathways can facilitate replacement by providing a mechanistic framework for identifying...
6.
Hoffmann S, Aiassa E, Angrish M, Beausoleil C, Bois F, Ciccolallo L, et al.
ALTEX
. 2022 Mar;
39(3):499–518.
PMID: 35258090
The workshop titled “Application of evidence-based methods to construct mechanism-driven chemical assessment frameworks” was co-organized by the Evidence-based Toxicology Collaboration and the European Food Safety Authority (EFSA) and hosted by...
7.
Korn D, Thieme A, Alves V, Yeakey M, Borba J, Capuzzi S, et al.
Drug Discov Today
. 2022 Feb;
27(6):1671-1678.
PMID: 35182735
Here, we propose a broad concept of 'Clinical Outcome Pathways' (COPs), which are defined as a series of key molecular and cellular events that underlie therapeutic effects of drug molecules....
8.
Hoer D, Barton H, Paini A, Bartels M, Ingle B, Domoradzki J, et al.
Toxicol Appl Pharmacol
. 2022 Feb;
440:115922.
PMID: 35176293
Although external concentrations are more readily quantified and often used as the metric for regulating and mitigating exposures to environmental chemicals, the toxicological response to an environmental chemical is more...
9.
LaLone C, Basu N, Browne P, Edwards S, Embry M, Sewell F, et al.
Environ Toxicol Chem
. 2021 Sep;
40(12):3226-3233.
PMID: 34551147
No abstract available.
10.
De Vries R, Angrish M, Browne P, Brozek J, Rooney A, Wikoff D, et al.
ALTEX
. 2021 Apr;
38(2):336-347.
PMID: 33837437
The workshop “Application of evidence-based methods to construct mechanistic frameworks for the development and use of non-animal toxicity tests” was organized by the Evidence-based Toxicology Collaboration and hosted by the...