Stephen R Sprang
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Explore the profile of Stephen R Sprang including associated specialties, affiliations and a list of published articles.
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1083
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Recent Articles
1.
Bosco J, Gagliano E, Boshae K, Statz J, Wheeler T, Cuello D, et al.
Sci Rep
. 2025 Mar;
15(1):8936.
PMID: 40089537
Protein production using Escherichia coli is a cornerstone of modern biotechnology. In this study, we developed a novel auto-expression medium to maximize protein production. Each E. coli strain tested was...
2.
Mou T, Zeng B, Doukov T, Sprang S
Acta Crystallogr D Struct Biol
. 2022 Aug;
78(Pt 8):1021-1031.
PMID: 35916226
The application of sulfur single-wavelength anomalous dispersion (S-SAD) to determine the crystal structures of macromolecules can be challenging if the asymmetric unit is large, the crystals are small, the size...
3.
Kerchner K, Mou T, Sun Y, Rusnac D, Sprang S, Briknarova K
J Struct Biol X
. 2021 Jul;
5:100050.
PMID: 34278292
Euchromatic histone-lysine N-methyltransferase 1 (EHMT1; G9a-like protein; GLP) and euchromatic histone-lysine N-methyltransferase 2 (EHMT2; G9a) are protein lysine methyltransferases that regulate gene expression and are essential for development and the...
4.
McClelland L, Zhang K, Mou T, Johnston J, Yates-Hansen C, Li S, et al.
Nat Commun
. 2020 Feb;
11(1):1077.
PMID: 32103024
Ric-8A is a cytosolic Guanine Nucleotide exchange Factor (GEF) that activates heterotrimeric G protein alpha subunits (Gα) and serves as an essential Gα chaperone. Mechanisms by which Ric-8A catalyzes these...
5.
Zeng B, Mou T, Doukov T, Steiner A, Yu W, Papasergi-Scott M, et al.
Structure
. 2019 Jun;
27(7):1137-1147.e5.
PMID: 31155309
Ric-8A is a 530-amino acid cytoplasmic molecular chaperone and guanine nucleotide exchange factor (GEF) for i, q, and 12/13 classes of heterortrimeric G protein alpha subunits (Gα). We report the...
6.
Maziarz M, Leyme A, Marivin A, Luebbers A, Patel P, Chen Z, et al.
J Biol Chem
. 2018 Oct;
293(51):19586-19599.
PMID: 30352874
The causative role of G protein-coupled receptor (GPCR) pathway mutations in uveal melanoma (UM) has been well-established. Nearly all UMs bear an activating mutation in a GPCR pathway mediated by...
7.
Stump S, Mou T, Sprang S, Natale N, Beall H
PLoS One
. 2018 Oct;
13(10):e0205584.
PMID: 30312328
The c-MYC oncogene mediates multiple tumor cell survival pathways and is dysregulated or overexpressed in the majority of human cancers. The NHE III1 region of the c-MYC promoter forms a...
8.
Kant R, Zeng B, Thomas C, Bothner B, Sprang S
Elife
. 2016 Dec;
5.
PMID: 28008853
Cytosolic Ric-8A has guanine nucleotide exchange factor (GEF) activity and is a chaperone for several classes of heterotrimeric G protein α subunits in vertebrates. Using Hydrogen-Deuterium Exchange-Mass Spectrometry (HDX-MS) we...
9.
McClelland L, Steele H, Whitby F, Mou T, Holley D, Ross J, et al.
J Am Chem Soc
. 2016 Dec;
138(51):16770-16778.
PMID: 27990813
Cytochrome c can acquire peroxidase activity when it binds to cardiolipin in mitochondrial membranes. The resulting oxygenation of cardiolipin by cytochrome c provides an early signal for the onset of...
10.
Yi F, Mou T, Dorsett K, Volkmann R, Menniti F, Sprang S, et al.
Neuron
. 2016 Sep;
91(6):1316-1329.
PMID: 27618671
NMDA receptors mediate excitatory synaptic transmission and regulate synaptic plasticity in the central nervous system, but their dysregulation is also implicated in numerous brain disorders. Here, we describe GluN2A-selective negative...