Stephen R Spindler
Overview
Explore the profile of Stephen R Spindler including associated specialties, affiliations and a list of published articles.
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34
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2324
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Recent Articles
1.
Spindler S, Mote P, Flegal J
Age (Dordr)
. 2016 Sep;
38(5-6):379-391.
PMID: 27590905
Statins, such as simvastatin, and ACE inhibitors (ACEis), such as ramipril, are standard therapies for the prevention and treatment of cardiovascular diseases. These types of drugs are commonly administered together....
2.
Dhahbi J, Atamna H, Li R, Yamakawa A, Guerrero N, Lam H, et al.
Genomics Insights
. 2016 Apr;
9:29-39.
PMID: 27042094
In mammals, extracellular miRNAs circulate in biofluids as stable entities that are secreted by normal and diseased tissues, and can enter cells and regulate gene expression. Drosophila melanogaster is a...
3.
Vuong L, Chellappa K, Dhahbi J, Deans J, Fang B, Bolotin E, et al.
Mol Cell Biol
. 2015 Aug;
35(20):3471-90.
PMID: 26240283
The nuclear receptor hepatocyte nuclear factor 4α (HNF4α) is tumor suppressive in the liver but amplified in colon cancer, suggesting that it also might be oncogenic. To investigate whether this...
4.
Victoria B, Dhahbi J, Nunez Lopez Y, Spinel L, Atamna H, Spindler S, et al.
Aging Cell
. 2015 Jul;
14(6):1055-66.
PMID: 26176567
Recent evidence demonstrates that serum levels of specific miRNAs significantly change with age. The ability of circulating sncRNAs to act as signaling molecules and regulate a broad spectrum of cellular...
5.
Victoria Martinez B, Dhahbi J, Nunez Lopez Y, Lamperska K, Golusinski P, Luczewski L, et al.
Oncotarget
. 2015 Jun;
6(22):19246-63.
PMID: 26057471
The Head and Neck Squamous Cell Carcinoma (HNSCC) is the sixth most common human cancer, causing 350,000 individuals die worldwide each year. The overall prognosis in HNSCC patients has not...
6.
Longo V, Antebi A, Bartke A, Barzilai N, Brown-Borg H, Caruso C, et al.
Aging Cell
. 2015 Apr;
14(4):497-510.
PMID: 25902704
The workshop entitled 'Interventions to Slow Aging in Humans: Are We Ready?' was held in Erice, Italy, on October 8-13, 2013, to bring together leading experts in the biology and...
7.
Dhahbi J, Spindler S, Atamna H, Boffelli D, Martin D
Biomark Cancer
. 2014 Dec;
6:37-47.
PMID: 25520563
Small noncoding RNAs circulating in the blood may serve as signaling molecules because of their ability to carry out a variety of cellular functions. We have previously described tRNA- and...
8.
Spindler S, Mote P, Lublin A, Flegal J, Dhahbi J, Li R
J Gerontol A Biol Sci Med Sci
. 2014 Nov;
70(12):1479-89.
PMID: 25380600
Mesonordihydroguaiaretic acid (NDGA) extends murine lifespan. The studies reported here describe its dose dependence, effects on body weight, toxicity-related clinical chemistries, and mortality-related pathologies. In flies, we characterized its effects...
9.
Spindler S, Mote P, Flegal J
Age (Dordr)
. 2014 May;
36(3):9659.
PMID: 24816553
Marine oils rich in ω-3 polyunsaturated fatty acids have been recommended as a preventive treatment for patients at risk for cardiovascular diseases. These oils also are the third most consumed...
10.
Spindler S, Mote P, Flegal J
Age (Dordr)
. 2013 Dec;
36(2):705-18.
PMID: 24370781
Present data suggest that the consumption of individual dietary supplements does not enhance the health or longevity of healthy rodents or humans. It might be argued that more complex combinations...