Stephen Newhouse
Overview
Explore the profile of Stephen Newhouse including associated specialties, affiliations and a list of published articles.
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Articles
33
Citations
1477
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Recent Articles
1.
Sherva R, Gross A, Mukherjee S, Koesterer R, Amouyel P, Bellenguez C, et al.
Alzheimers Dement
. 2020 Jun;
16(8):1134-1145.
PMID: 32573913
Introduction: Variability exists in the disease trajectories of Alzheimer's disease (AD) patients. We performed a genome-wide association study to examine rate of cognitive decline (ROD) in patients with AD. Methods:...
2.
Traylor M, Knevel R, Cui J, Taylor J, Harm-Jan W, Conaghan P, et al.
PLoS One
. 2019 Oct;
14(10):e0223246.
PMID: 31596875
Background: Previous studies of radiological damage in rheumatoid arthritis (RA) have used candidate-gene approaches, or evaluated single genome-wide association studies (GWAS). We undertook the first meta-analysis of GWAS of RA...
3.
Santoro M, Ota V, de Jong S, Noto C, Spindola L, Talarico F, et al.
Transl Psychiatry
. 2018 Sep;
8(1):174.
PMID: 30171181
In this study, we aimed to test if the schizophrenia (SCZ) polygenic risk score (PRS) was associated with clinical symptoms in (a) the first episode of psychosis pre-treatment (FEP), (b)...
4.
Fabbri C, Tansey K, Perlis R, Hauser J, Henigsberg N, Maier W, et al.
Eur Neuropsychopharmacol
. 2018 Aug;
28(8):945-954.
PMID: 30135031
Cytochrome (CYP) P450 enzymes have a primary role in antidepressant metabolism and variants in these polymorphic genes are targets for pharmacogenetic investigation. This is the first meta-analysis to investigate how...
5.
Gardner K, Fulford T, Silver N, Rooks H, Angelis N, Allman M, et al.
Blood Adv
. 2018 Feb;
2(3):235-239.
PMID: 29437638
Fetal hemoglobin (HbF) is a strong modifier of sickle cell disease (SCD) severity and is associated with 3 common genetic loci. Quantifying the genetic effects of the 3 loci would...
6.
Baker E, Iqbal E, Johnston C, Broadbent M, Shetty H, Stewart R, et al.
PLoS One
. 2017 Jun;
12(6):e0178562.
PMID: 28591196
Background: Modeling trajectories of decline can help describe the variability in progression of cognitive impairment in dementia. Better characterisation of these trajectories has significant implications for understanding disease progression, trial...
7.
Traylor M, Curtis C, Patel H, Breen G, Lee S, Xu X, et al.
Rheumatology (Oxford)
. 2017 Apr;
56(8):1282-1292.
PMID: 28407095
Objectives: To evaluate whether genetic and environmental factors associated with RA in European and Asian ancestry populations are also associated with RA in African ancestry individuals. Methods: A case-control study...
8.
Altimiras F, Uszczynska-Ratajczak B, Camara F, Vlasova A, Palumbo E, Newhouse S, et al.
Front Aging Neurosci
. 2017 Apr;
9:64.
PMID: 28373841
No abstract available.
9.
Traylor M, Rutten-Jacobs L, Curtis C, Patel H, Breen G, Newhouse S, et al.
Neurol Genet
. 2017 Mar;
3(2):e142.
PMID: 28349126
Objective: Despite epidemiologic data showing an increased stroke incidence in African ancestry populations, genetic studies in this group have so far been limited, and there has been little characterization of...
10.
Lunnon K, Keohane A, Pidsley R, Newhouse S, Riddoch-Contreras J, Thubron E, et al.
Neurobiol Aging
. 2017 Feb;
53:36-47.
PMID: 28208064
Although mitochondrial dysfunction is a consistent feature of Alzheimer's disease in the brain and blood, the molecular mechanisms behind these phenomena are unknown. Here we have replicated our previous findings...