Stephen N Thibodeau
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Explore the profile of Stephen N Thibodeau including associated specialties, affiliations and a list of published articles.
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326
Citations
19963
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Recent Articles
1.
Lin H, Mazumder H, Sarkar I, Huang P, Eeles R, Kote-Jarai Z, et al.
Sci Rep
. 2024 Aug;
14(1):18677.
PMID: 39134575
Single nucleotide polymorphism (SNP) interactions are the key to improving polygenic risk scores. Previous studies reported several significant SNP-SNP interaction pairs that shared a common SNP to form a cluster,...
2.
Tian Y, Lin Y, Qu C, Arndt V, Baurley J, Berndt S, et al.
Br J Cancer
. 2024 Apr;
130(10):1687-1696.
PMID: 38561434
Background: Menopausal hormone therapy (MHT), a common treatment to relieve symptoms of menopause, is associated with a lower risk of colorectal cancer (CRC). To inform CRC risk prediction and MHT...
3.
Papadimitriou N, Qu C, Harrison T, Bever A, Martin R, Tsilidis K, et al.
EBioMedicine
. 2024 Feb;
101:105010.
PMID: 38350331
Background: Obesity has been positively associated with most molecular subtypes of colorectal cancer (CRC); however, the magnitude and the causality of these associations is uncertain. Methods: We used Mendelian randomization...
4.
Wang A, Shen J, Rodriguez A, Saunders E, Chen F, Janivara R, et al.
Nat Genet
. 2023 Nov;
55(12):2065-2074.
PMID: 37945903
The transferability and clinical value of genetic risk scores (GRSs) across populations remain limited due to an imbalance in genetic studies across ancestrally diverse populations. Here we conducted a multi-ancestry...
5.
Dimou N, Kim A, Flanagan O, Murphy N, Diez-Obrero V, Shcherbina A, et al.
Br J Cancer
. 2023 Jun;
129(3):511-520.
PMID: 37365285
Background: Diabetes is an established risk factor for colorectal cancer. However, the mechanisms underlying this relationship still require investigation and it is not known if the association is modified by...
6.
Darst B, Shen J, Madduri R, Rodriguez A, Xiao Y, Sheng X, et al.
Am J Hum Genet
. 2023 Jun;
110(7):1200-1206.
PMID: 37311464
Genome-wide polygenic risk scores (GW-PRSs) have been reported to have better predictive ability than PRSs based on genome-wide significance thresholds across numerous traits. We compared the predictive ability of several...
7.
Darst B, Shen J, Madduri R, Rodriguez A, Xiao Y, Sheng X, et al.
medRxiv
. 2023 Jun;
PMID: 37292833
Genome-wide polygenic risk scores (GW-PRS) have been reported to have better predictive ability than PRS based on genome-wide significance thresholds across numerous traits. We compared the predictive ability of several...
8.
Aglago E, Kim A, Lin Y, Qu C, Evangelou M, Ren Y, et al.
Cancer Res
. 2023 May;
83(15):2572-2583.
PMID: 37249599
Significance: This gene-environment interaction analysis revealed a genetic locus in FMN1/GREM1 that interacts with body mass index in colorectal cancer risk, suggesting potential implications for precision prevention strategies.
9.
Dominguez-Valentin M, Haupt S, Seppala T, Sampson J, Sunde L, Bernstein I, et al.
EClinicalMedicine
. 2023 May;
58:101909.
PMID: 37181409
Background: The Prospective Lynch Syndrome Database (PLSD) collates information on carriers of pathogenic or likely pathogenic MMR variants () who are receiving medical follow-up, including colonoscopy surveillance, which aims to...
10.
Ugai T, Haruki K, Harrison T, Cao Y, Qu C, Chan A, et al.
Am J Gastroenterol
. 2023 Jan;
118(4):712-726.
PMID: 36707929
Introduction: Early-onset colorectal cancer diagnosed before the age of 50 years has been increasing. Likely reflecting the pathogenic role of the intestinal microbiome, which gradually changes across the entire colorectal...