Stephen N Floor
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Explore the profile of Stephen N Floor including associated specialties, affiliations and a list of published articles.
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45
Citations
3975
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Recent Articles
1.
Liboy-Lugo J, Espinoza C, Sheu-Gruttadauria J, Park J, Xu A, Jowhar Z, et al.
Mol Biol Cell
. 2024 Oct;
35(11):ar140.
PMID: 39356796
Stress granules (SGs) are macromolecular assemblies that form under cellular stress. Formation of these membraneless organelles is driven by the condensation of RNA and RNA-binding proteins such as G3BPs. G3BPs...
2.
Ietswaart R, Smalec B, Xu A, Choquet K, McShane E, Jowhar Z, et al.
Mol Cell
. 2024 Jul;
84(14):2765-2784.e16.
PMID: 38964322
Dissecting the regulatory mechanisms controlling mammalian transcripts from production to degradation requires quantitative measurements of mRNA flow across the cell. We developed subcellular TimeLapse-seq to measure the rates at which...
3.
Park J, Desai H, Liboy-Lugo J, Gu S, Jowhar Z, Xu A, et al.
Life Sci Alliance
. 2024 May;
7(8).
PMID: 38803225
IGHMBP2 is a nonessential, superfamily 1 DNA/RNA helicase that is mutated in patients with rare neuromuscular diseases SMARD1 and CMT2S. IGHMBP2 is implicated in translational and transcriptional regulation via biochemical...
4.
Wilkins K, Schroeder T, Gu S, Revalde J, Floor S
RNA
. 2024 May;
30(8):1041-1057.
PMID: 38697667
DDX3X regulates the translation of a subset of human transcripts containing complex 5' untranslated regions (5' UTRs). In this study, we developed the helicase activity reporter for translation (HART), which...
5.
Liboy-Lugo J, Espinoza C, Sheu-Gruttadauria J, Park J, Xu A, Jowhar Z, et al.
bioRxiv
. 2024 Feb;
PMID: 38370785
Stress granules (SGs) are macromolecular assemblies that form under cellular stress. Formation of these condensates is driven by the condensation of RNA and RNA-binding proteins such as G3BPs. G3BPs condense...
6.
Jowhar Z, Xu A, Venkataramanan S, Dossena F, Hoye M, Silver D, et al.
Mol Syst Biol
. 2024 Jan;
20(3):276-290.
PMID: 38273160
The road from transcription to protein synthesis is paved with many obstacles, allowing for several modes of post-transcriptional regulation of gene expression. A fundamental player in mRNA biology is DDX3X,...
7.
Park J, Desai H, Liboy-Lugo J, Gu S, Jowhar Z, Xu A, et al.
bioRxiv
. 2024 Jan;
PMID: 38168189
IGHMBP2 is a non-essential, superfamily 1 DNA/RNA helicase that is mutated in patients with rare neuromuscular diseases SMARD1 and CMT2S. IGHMBP2 is implicated in translational and transcriptional regulation via biochemical...
8.
Lin Y, Kwok S, Hein A, Thai B, Alabi Y, Ostrowski M, et al.
Nat Methods
. 2023 Oct;
20(12):1887-1899.
PMID: 37857907
RNA deaminases are powerful tools for base editing and RNA molecular recording. However, the enzymes used in currently available RNA molecular recorders such as TRIBE, DART or STAMP have limitations...
9.
Subramanian A, Wang L, Moss T, Voorhies M, Sangwan S, Stevenson E, et al.
Nat Cell Biol
. 2023 Oct;
25(11):1600-1615.
PMID: 37857833
A widespread strategy employed by pathogens to establish infection is to inhibit host-cell protein synthesis. Legionella pneumophila, an intracellular bacterial pathogen and the causative organism of Legionnaires' disease, secretes a...
10.
Sheu-Gruttadauria J, Yan X, Stuurman N, Vale R, Floor S
bioRxiv
. 2023 Oct;
PMID: 37808656
Ribosome biogenesis occurs in the nucleolus, a nuclear biomolecular condensate that exhibits dynamic biophysical properties thought to be important for function. However, the relationship between ribosome assembly and nucleolar dynamics...