Stephen M Christensen
Overview
Explore the profile of Stephen M Christensen including associated specialties, affiliations and a list of published articles.
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15
Citations
414
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Recent Articles
1.
Krishna C, Chiou J, Sakaue S, Kang J, Christensen S, Lee I, et al.
Nat Commun
. 2024 Jul;
15(1):6469.
PMID: 39085222
Genetic variation in the human leukocyte antigen (HLA) loci is associated with risk of immune-mediated diseases, but the molecular effects of HLA polymorphism are unclear. Here we examined the effects...
2.
West G, Zhao S, Nguyen Q, Christensen S, Gordon I, Holubar S, et al.
STAR Protoc
. 2023 Nov;
4(4):102686.
PMID: 37925636
Single-cell isolation techniques allow the investigation of physical and functional relationships between individual cells within a complex cell population. Here, we present a protocol for single-cell isolation from full-thickness intestinal...
3.
Spolski R, Li P, Chandra V, Shin B, Goel S, Sakamoto K, et al.
Sci Immunol
. 2023 Nov;
8(89):eadi8217.
PMID: 37922339
The IL-2 receptor α chain (IL-2Rα/CD25) is constitutively expressed on double-negative (DN2/DN3 thymocytes and regulatory T cells (T) but induced by IL-2 on T and natural killer (NK) cells, with...
4.
Mukherjee P, Nguyen Q, Li J, Zhao S, Christensen S, West G, et al.
Gastroenterology
. 2023 Jul;
165(5):1180-1196.
PMID: 37507073
Background & Aims: Fibroblasts play a key role in stricture formation in Crohn's disease (CD) but understanding its pathogenesis requires a systems-level investigation to uncover new treatment targets. We studied...
5.
Mukherjee P, Nguyen Q, Li J, Zhao S, Christensen S, West G, et al.
bioRxiv
. 2023 Apr;
PMID: 37066202
Background: Fibroblasts play a key role in stricture formation in Crohn's disease (CD) but understanding it's pathogenesis requires a systems-level investigation to uncover new treatment targets. We studied full thickness...
6.
Fabre T, Barron A, Christensen S, Asano S, Bound K, Lech M, et al.
Sci Immunol
. 2023 Apr;
8(82):eadd8945.
PMID: 37027478
Macrophages are central orchestrators of the tissue response to injury, with distinct macrophage activation states playing key roles in fibrosis progression and resolution. Identifying key macrophage populations found in human...
7.
Argyriou A, Wadsworth 2nd M, Lendvai A, Christensen S, Hensvold A, Gerstner C, et al.
Nat Commun
. 2022 Jul;
13(1):4046.
PMID: 35831277
Rheumatoid arthritis (RA) is an autoimmune disease affecting synovial joints where different CD4 T cell subsets may contribute to pathology. Here, we perform single cell sequencing on synovial CD4 T...
8.
McCann K, Christensen S, Colby D, McGuire P, Myles I, Zerbe C, et al.
Blood Adv
. 2022 May;
6(12):3821-3834.
PMID: 35500221
Interferon γ (IFNγ) is an essential and pleiotropic activator of human monocytes, but little is known about the changes in cellular metabolism required for IFNγ-induced activation. We sought to elucidate...
9.
Goncalves R, Christensen S, Mosser D
Cytokine X
. 2021 Feb;
2(4):100046.
PMID: 33604564
Leishmaniasis can present as a "spectrum" of clinical outcomes. There is evidence that these divergent clinical outcomes are attributable to genetic differences in the human host [1] as well the...
10.
Dalby E, Christensen S, Wang J, Hamidzadeh K, Chandrasekaran P, Hughitt V, et al.
J Immunol
. 2020 May;
205(1):102-112.
PMID: 32434940
To maintain homeostasis, macrophages must be capable of assuming either an inflammatory or an anti-inflammatory phenotype. To better understand the latter, we stimulated human macrophages in vitro with TLR ligands...