» Authors » Stephen Leslie

Stephen Leslie

Explore the profile of Stephen Leslie including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 45
Citations 9097
Followers 0
Related Specialties
Top 10 Co-Authors
Published In
Affiliations
Soon will be listed here.
Recent Articles
1.
Motyer A, Jackson S, Yang B, Harliwong I, Tian W, Shiu W, et al.
Nat Neurosci . 2025 Mar; PMID: 40038527
Neuroinflammation underpins neurodegeneration and clinical progression in multiple sclerosis (MS), but knowledge of processes linking these disease mechanisms remains incomplete. Here we investigated somatic single-nucleotide variants (sSNVs) in the genomes...
2.
Callum K, Swinton P, Gorely T, Crabtree D, Leslie S
Heart Lung . 2023 Dec; 64:117-127. PMID: 38159428
Background: An important component of secondary prevention of CVD (including HF) is comprehensive cardiac rehab, including exercise. Novel, individualised approaches are needed to increase uptake and adherence to exercise programmes,...
3.
Silcocks M, Farlow A, Hermes A, Tsambos G, Patel H, Huebner S, et al.
Nature . 2023 Dec; 624(7992):593-601. PMID: 38093005
The Indigenous peoples of Australia have a rich linguistic and cultural history. How this relates to genetic diversity remains largely unknown because of their limited engagement with genomic studies. Here...
4.
Tsambos G, Kelleher J, Ralph P, Leslie S, Vukcevic D
Bioinform Adv . 2023 Nov; 3(1):vbad163. PMID: 38033661
Summary: It is challenging to simulate realistic tracts of genetic ancestry on a scale suitable for simulation-based inference. We present an algorithm that enables this information to be extracted efficiently...
5.
Abberton K, McDonald T, Diviney M, Holdsworth R, Leslie S, Delatycki M, et al.
Stem Cells Transl Med . 2022 Sep; 11(10):1052-1060. PMID: 36073721
We aim to create a bank of clinical grade cord blood-derived induced pluripotent stem cell lines in order to facilitate clinical research leading to the development of new cellular therapies....
6.
Harrison G, Leaton L, Harrison E, Kichula K, Viken M, Shortt J, et al.
PLoS Comput Biol . 2022 Feb; 18(2):e1009059. PMID: 35192601
Highly polymorphic interaction of KIR3DL1 and KIR3DS1 with HLA class I ligands modulates the effector functions of natural killer (NK) cells and some T cells. This genetically determined diversity affects...
7.
Ahn R, Vukcevic D, Motyer A, Nititham J, Squire D, Hollenbach J, et al.
Front Immunol . 2021 Jun; 12:684326. PMID: 34177931
Killer cell immunoglobulin-like receptors (KIR) regulate immune responses in NK and CD8+ T cells interaction with HLA ligands. KIR genes, including KIR2DS1, KIR3DL1, and KIR3DS1 have previously been implicated in...
8.
Akinosun A, Polson R, Diaz-Skeete Y, De Kock J, Carragher L, Leslie S, et al.
JMIR Mhealth Uhealth . 2021 Mar; 9(3):e21061. PMID: 33656444
Background: Approximately 50% of cardiovascular disease (CVD) cases are attributable to lifestyle risk factors. Despite widespread education, personal knowledge, and efficacy, many individuals fail to adequately modify these risk factors,...
9.
Degenhardt F, Mayr G, Wendorff M, Boucher G, Ellinghaus E, Ellinghaus D, et al.
Hum Mol Genet . 2021 Feb; 30(5):356-369. PMID: 33555323
Inflammatory bowel disease (IBD) is a chronic inflammatory disease of the gut. Genetic association studies have identified the highly variable human leukocyte antigen (HLA) region as the strongest susceptibility locus...
10.
Hanson A, Vukcevic D, Leslie S, Harris J, Le Cao K, Kenna T, et al.
PLoS Genet . 2020 Aug; 16(8):e1008906. PMID: 32804949
The killer immunoglobulin-like receptors (KIRs), found predominantly on the surface of natural killer (NK) cells and some T-cells, are a collection of highly polymorphic activating and inhibitory receptors with variable...