Stephen L Bearne
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Explore the profile of Stephen L Bearne including associated specialties, affiliations and a list of published articles.
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71
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Recent Articles
1.
Sorbara N, Black A, Bearne S
Bioorg Med Chem Lett
. 2025 Mar;
:130160.
PMID: 40037494
Isoleucine 2-epimerase from Lactobacillus buchneri (LbIleE) catalyzes the pyridoxal 5'-phosphate-dependent, reversible, racemization or epimerization of nonpolar amino acids at the C-2 position. The integral role of the enzyme in the...
2.
Kumar H, Kuehm O, Aboushawareb S, Rafiei A, Easton N, Bearne S
Biochemistry
. 2025 Jan;
64(3):666-677.
PMID: 39835335
Enzymes of the enolase superfamily (ENS) are mechanistically diverse, yet share a common partial reaction, i.e., the metal-assisted, Bro̷nsted base-catalyzed abstraction of the α-proton from a carboxylate substrate to form...
3.
Bearne S
Bioessays
. 2024 Jul;
46(8):e2400063.
PMID: 38975656
A host of metabolic enzymes reversibly self-assemble to form membrane-less, intracellular filaments under normal physiological conditions and in response to stress. Often, these enzymes reside at metabolic control points, suggesting...
4.
McGary L, Fetter C, Gu M, Hamilton M, Kumar H, Kuehm O, et al.
Arch Biochem Biophys
. 2024 Feb;
754:109924.
PMID: 38354877
Enzymes of the enolase superfamily share a conserved structure and a common partial reaction (i.e., metal-assisted, Brønsted base-catalyzed enol(ate) formation). The architectures of the enolization apparatus at the active sites...
5.
Bearne S
Methods Enzymol
. 2023 Oct;
690:397-444.
PMID: 37858537
Racemases and epimerases catalyze the inversion of stereochemistry at asymmetric carbon atoms to generate stereoisomers that often play important roles in normal and pathological physiology. Consequently, there is interest in...
6.
McGary L, Regan G, Bearne S
Biochim Biophys Acta Proteins Proteom
. 2023 Aug;
1871(6):140945.
PMID: 37536394
Activity-based protein profiling has facilitated the study of the activity of enzymes in proteomes, inhibitor development, and identification of enzymes that share mechanistic and active-site architectural features. Since methyl acyl...
7.
Kuehm O, Hayden J, Bearne S
Biochemistry
. 2023 Jun;
62(12):1929-1942.
PMID: 37285384
Mandelate racemase (MR) catalyzes the Mg-dependent interconversion of ()- and ()-mandelate by stabilizing the altered substrate in the transition state (TS) by ∼26 kcal/mol. The enzyme has been employed as...
8.
Bearne S, Hayden J
Methods Enzymol
. 2023 May;
685:127-169.
PMID: 37245900
Racemases and epimerases have attracted much interest because of their astonishing ability to catalyze the rapid α-deprotonation of carbon acid substrates with high pK values (∼13-30) leading to the formation...
9.
McLeod M, Tran N, McCluskey G, Gillis T, Bearne S, Holyoak T
Protein Sci
. 2023 Apr;
32(6):e4648.
PMID: 37106216
CTP synthases (CTPS) catalyze the de novo production of CTP using UTP, ATP, and l-glutamine with the anticancer drug metabolite gemcitabine-5'-triphosphate (dF-dCTP) being one of its most potent nucleotide inhibitors....
10.
Richards N, Bearne S, Goto Y, Parker E
Philos Trans R Soc Lond B Biol Sci
. 2023 Jan;
378(1871):20220023.
PMID: 36633278
Physical organic chemistry and mechanistic thinking provide a strong intellectual framework for understanding the chemical logic of evolvable informational macromolecules and metabolic transformations in living organisms. These concepts have also...