Stephen J Hierons
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Explore the profile of Stephen J Hierons including associated specialties, affiliations and a list of published articles.
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6
Citations
24
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Recent Articles
1.
Gibson S, Frost I, Hierons S, Moses T, Poon W, West S, et al.
Nat Commun
. 2025 Feb;
16(1):1400.
PMID: 39948360
Bacterial death is critical in nutrient recycling. However, the underlying mechanisms that permit macromolecule recycling after bacterial death are largely unknown. We demonstrate that bacteria encode post-mortem protein catabolism via...
2.
Lu J, Hierons S, Arya S, Fritzen R, Polepalli S, Khazaipoul S, et al.
Chem Commun (Camb)
. 2025 Jan;
61(10):2099-2102.
PMID: 39801276
The foetal plasma protein α-fetoprotein (AFP) harbours a high-affinity zinc binding site that is likely involved in transport and delivery of essential zinc during foetal development. Based on a recent...
3.
Wu D, Hierons S, Polepalli S, Gucwa M, Fritzen R, Markiewicz M, et al.
J Lipid Res
. 2024 May;
65(6):100560.
PMID: 38750995
Zinc is required for virtually all biological processes. In plasma, Zn is predominantly transported by human serum albumin (HSA), which possesses two Zn-binding sites of differing affinities (sites A and...
4.
Abbas K, Hierons S, Pechlivani N, Phoenix F, Alexander R, King R, et al.
Res Pract Thromb Haemost
. 2024 Mar;
8(2):102361.
PMID: 38545128
Background: Obesity is a complex condition associated with prothrombotic fibrin networks that are resistant to fibrinolysis. Altered fibrin clot properties enhance cardiovascular risk and associate with a poorer prognosis following...
5.
Regan-Smith S, Fritzen R, Hierons S, Ajjan R, Blindauer C, Stewart A
Int J Mol Sci
. 2022 Sep;
23(18).
PMID: 36142215
The initiation, maintenance and regulation of blood coagulation is inexorably linked to the actions of Zn in blood plasma. Zn interacts with a variety of haemostatic proteins in the bloodstream...
6.
Hierons S, Abbas K, Sobczak A, Cerone M, Smith T, Ajjan R, et al.
Sci Rep
. 2022 Sep;
12(1):15337.
PMID: 36097032
Obesity is a complex disease that increases an individual's risk of developing other diseases and health-related problems. A common feature is dyslipidemia characterized by increased levels of plasma lipids, which...
7.
Hierons S, Catchpole A, Abbas K, Wong W, Giles M, Miller G, et al.
Biometals
. 2022 Feb;
36(2):241-253.
PMID: 35138503
Obesity enhances the risk of type-2 diabetes, cardiovascular disease and inflammatory conditions and often leads to metal dyshomeostasis, which contributes to the negative health aspects associated with the disease. In...
8.
Hierons S, Marsh J, Wu D, Blindauer C, Stewart A
Int J Mol Sci
. 2021 Sep;
22(18).
PMID: 34576303
Thrombosis is a major comorbidity of obesity and type-2 diabetes mellitus (T2DM). Despite the development of numerous effective treatments and preventative strategies to address thrombotic disease in such individuals, the...