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Stephen J Fey

Explore the profile of Stephen J Fey including associated specialties, affiliations and a list of published articles. Areas
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Articles 18
Citations 317
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Recent Articles
1.
Poulsen M, Dastidar S, Roy D, Palchoudhuri S, Kristiansen J, Fey S
Molecules . 2022 Jan; 27(1). PMID: 35011432
The rising tide of antibacterial drug resistance has given rise to the virtual elimination of numerous erstwhile antibiotics, intensifying the urgent demand for novel agents. A number of drugs have...
2.
Wrzesinski K, Frandsen H, Calitz C, Gouws C, Korzeniowska B, Fey S
Methods Mol Biol . 2021 Feb; 2273:17-62. PMID: 33604843
Growing cells as 3D structures need not be difficult. Often, it is not necessary to change cell type, additives or growth media used. All that needs to be changed is...
3.
Fey S, Korzeniowska B, Wrzesinski K
Toxicol Res (Camb) . 2020 Sep; 9(4):379-389. PMID: 32905230
Medicines are usually prescribed for repeated use over shorter or longer times. Unfortunately, repeated-dose animal toxicity studies do not correlate well with observations in man. As emphasized by the '3Rs'...
4.
Smit T, Calitz C, Willers C, Svitina H, Hamman J, Fey S, et al.
ACS Med Chem Lett . 2020 May; 11(5):1014-1021. PMID: 32435419
Colorectal cancer is one of the leading causes of cancer-related deaths. A main problem for its treatment is resistance to chemotherapy, requiring the development of new drugs. The success rate...
5.
Calitz C, Hamman J, Fey S, Viljoen A, Gouws C, Wrzesinski K
J Ethnopharmacol . 2019 Apr; 239:111897. PMID: 31009705
Ethnopharmacology Relevance: Traditional herbal medicines are utilized by 27 million South Africans. Xysmalobium undulatum (Uzara) is one of the most widely used traditional medicinal plants in Southern Africa. A false...
6.
Wojdyla K, Wrzesinski K, Williamson J, Fey S, Rogowska-Wrzesinska A
Toxicol Res (Camb) . 2018 Aug; 5(3):905-920. PMID: 30090399
Acetaminophen (APAP) is possibly the most widely used medication globally and yet little is known of its molecular effects at therapeutic doses. Using a novel approach, we have analysed the...
7.
Calitz C, Hamman J, Viljoen A, Fey S, Wrzesinski K, Gouws C
Toxicol Mech Methods . 2018 Jun; 28(9):641-652. PMID: 29873580
Xysmalobium undulatum (Uzara) is one of the most widely used indigenous traditional herbal remedies in Southern Africa. Commercially available Uzara plant material was used to prepare a crude aqueous extract,...
8.
Wrzesinski K, Fey S
Bioengineering (Basel) . 2018 Mar; 5(1). PMID: 29518979
The recovery of physiological functionality, which is commonly seen in tissue mimetic three-dimensional (3D) cellular aggregates (organoids, spheroids, acini, etc.), has been observed in cells of many origins (primary tissues,...
9.
Calitz C, Hamman J, Fey S, Wrzesinski K, Gouws C
Toxicol Mech Methods . 2018 Jan; 28(5):369-385. PMID: 29297242
The liver is a vital organ fulfilling a central role in over 500 major metabolic functions, including serving as the most essential site for drug biotransformation. Dysfunction of the drug...
10.
Wrzesinski K, Fey S
Curr Pharm Des . 2015 Oct; 21(38):5605-16. PMID: 26429710
Natural products, or their synthetic derivatives are a treasure trove to find potential candidates for novel drugs for human treatment. The selection of diamonds from the huge pile of worthless...