Stephen J Barigye
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Explore the profile of Stephen J Barigye including associated specialties, affiliations and a list of published articles.
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Articles
51
Citations
280
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Recent Articles
1.
Sierra-Hernandez O, Saurith-Coronell O, Rodriguez-Macias J, Marquez E, Mora J, Paz J, et al.
Int J Mol Sci
. 2025 Feb;
26(4).
PMID: 40004190
The rise in multidrug-resistant bacteria highlights the critical need for novel antibiotics. This study explores clovibactin-like compounds as potential therapeutic agents targeting lipid II, a crucial component in bacterial cell...
2.
Martinez-Lopez Y, Phoobane P, Jauriga Y, Castillo-Garit J, Rodriguez-Gonzalez A, Martinez-Santiago O, et al.
J Mol Model
. 2024 Nov;
30(11):393.
PMID: 39485560
Context: This study investigates the potential of leveraging molecular properties, as determined by MD-LOVIs software and machine learning techniques, to predict the ability of compounds to cross the blood-brain barrier...
3.
Castillo-Mendieta K, Aguero-Chapin G, Marquez E, Perez-Castillo Y, Barigye S, Vispo N, et al.
NPJ Syst Biol Appl
. 2024 Oct;
10(1):115.
PMID: 39367008
Peptides are promising drug development frameworks that have been hindered by intrinsic undesired properties including hemolytic activity. We aim to get a better insight into the chemical space of hemolytic...
4.
Carpio L, Olivares M, Benitez-Paez A, Serrano-Candelas E, Barigye S, Sanz Y, et al.
Int J Mol Sci
. 2024 Jun;
25(11).
PMID: 38891933
The role of the gut microbiota and its interplay with host metabolic health, particularly in the context of type 2 diabetes mellitus (T2DM) management, is garnering increasing attention. Dipeptidyl peptidase...
5.
Castillo-Mendieta K, Aguero-Chapin G, Marquez E, Perez-Castillo Y, Barigye S, Perez-Cardenas M, et al.
Chem Res Toxicol
. 2024 Mar;
37(4):580-589.
PMID: 38501392
The desirable pharmacological properties and a broad number of therapeutic activities have made peptides promising drugs over small organic molecules and antibody drugs. Nevertheless, toxic effects, such as hemolysis, have...
6.
Mora J, Marquez E, Perez-Perez N, Contreras-Torres E, Perez-Castillo Y, Aguero-Chapin G, et al.
J Comput Aided Mol Des
. 2024 Feb;
38(1):9.
PMID: 38351144
Notwithstanding the wide adoption of the OECD principles (or best practices) for QSAR modeling, disparities between in silico predictions and experimental results are frequent, suggesting that model predictions are often...
7.
Exploring proteasome inhibition using atomic weighted vector indices and machine learning approaches
Martinez-Lopez Y, Castillo-Garit J, Casanola-Martin G, Rasulev B, Rodriguez-Gonzalez A, Martinez-Santiago O, et al.
Mol Divers
. 2023 Apr;
28(4):1983-1994.
PMID: 37017875
Ubiquitin-proteasome system (UPS) is a highly regulated mechanism of intracellular protein degradation and turnover. The UPS is involved in different biological activities, such as the regulation of gene transcription and...
8.
Ghafary S, Soriano-Teruel P, Lotfollahzadeh S, Sancho M, Serrano-Candelas E, Karami F, et al.
Int J Mol Sci
. 2022 Feb;
23(3).
PMID: 35163573
Inflammasomes are multiprotein complexes that represent critical elements of the inflammatory response. The dysregulation of the best-characterized complex, the NLRP3 inflammasome, has been linked to the pathogenesis of diseases such...
9.
Carpio L, Sanz Y, Gozalbes R, Barigye S
Mol Divers
. 2021 Jul;
25(3):1425-1438.
PMID: 34258685
Scientific and consumer interest in healthy foods (also known as functional foods), nutraceuticals and cosmeceuticals has increased in the recent years, leading to an increased presence of these products in...
10.
Goya-Jorge E, Amber M, Gozalbes R, Connolly L, Barigye S
Environ Toxicol Pharmacol
. 2021 Jun;
87:103688.
PMID: 34119701
Multiple substances are considered endocrine disrupting chemicals (EDCs). However, there is a significant gap in the early prioritization of EDC's effects. In this work, in silico and in vitro methods...