Stephen Hewitt
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Explore the profile of Stephen Hewitt including associated specialties, affiliations and a list of published articles.
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72
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3310
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Recent Articles
11.
Bodelon C, Mullooly M, Pfeiffer R, Fan S, Abubakar M, Lenz P, et al.
Breast Cancer Res
. 2021 Nov;
23(1):105.
PMID: 34753492
Background: Elevated mammographic breast density is a strong breast cancer risk factor with poorly understood etiology. Increased deposition of collagen, one of the main fibrous proteins present in breast stroma,...
12.
Roper N, Velez M, Chiappori A, Kim Y, Wei J, Sindiri S, et al.
Nat Commun
. 2021 Jun;
12(1):3880.
PMID: 34162872
Immune checkpoint blockade (ICB) benefits only a small subset of patients with small cell lung cancer (SCLC), yet the mechanisms driving benefit are poorly understood. To identify predictors of clinical...
13.
Huang N, Perez P, Kato T, Mikami Y, Okuda K, Gilmore R, et al.
medRxiv
. 2020 Nov;
PMID: 33140061
Despite signs of infection, the involvement of the oral cavity in COVID-19 is poorly understood. To address this, single-cell RNA sequencing data-sets were integrated from human minor salivary glands and...
14.
Takahashi N, Rajapakse V, Pongor L, Kumar S, Tlemsani C, Erwin-Cohen R, et al.
Cold Spring Harb Mol Case Stud
. 2020 Oct;
6(5).
PMID: 33028646
Mismatch repair-deficient (dMMR) cancers generate a substantial number of immunogenic neoantigens, rendering them sensitive to immunotherapy. Yet, there is considerable variability in responses, and roughly one-half of dMMR cancers are...
15.
Zeligs K, Morelli M, David J, Neuman M, Hernandez L, Hewitt S, et al.
Front Oncol
. 2020 Jul;
10:805.
PMID: 32637350
Despite high initial response rates with cytoreductive surgery, conventional chemotherapy and the incorporation of biologic agents, ovarian cancer patients often relapse and die from their disease. New approaches are needed...
16.
Roper N, Brown A, Wei J, Pack S, Trindade C, Kim C, et al.
Cell Rep Med
. 2020 Jun;
1(1).
PMID: 32483558
Clonal evolution of osimertinib-resistance mechanisms in EGFR mutant lung adenocarcinoma is poorly understood. Using multi-region whole-exome and RNA sequencing of prospectively collected pre- and post-osimertinib-resistant tumors, including at rapid autopsies,...
17.
Kos Z, Roblin E, Kim R, Michiels S, Gallas B, Chen W, et al.
NPJ Breast Cancer
. 2020 May;
6:17.
PMID: 32411819
Stromal tumor-infiltrating lymphocytes (sTILs) are important prognostic and predictive biomarkers in triple-negative (TNBC) and HER2-positive breast cancer. Incorporating sTILs into clinical practice necessitates reproducible assessment. Previously developed standardized scoring guidelines...
18.
Hewitt S, Kristinsson J, Aasheim E, Blom-Hogestol I, Aaseth E, Jahnsen J, et al.
Obes Surg
. 2020 Apr;
30(9):3426-3434.
PMID: 32306297
Purpose: Secondary hyperparathyroidism (SHPT) after obesity surgery may affect bone health. Optimal vitamin D levels have not been established to prevent SHPT postoperatively. We investigated whether SHPT differed across threshold...
19.
Kherad O, Peiffer-Smadja N, Karlafti L, Lember M, Van Aerde N, Gunnarsson O, et al.
Eur J Intern Med
. 2020 Apr;
76:1-7.
PMID: 32303454
The concept of Less is More medicine emerged in North America in 2010. It aims to serve as an invitation to recognize the potential risks of overuse of medical care...
20.
Gonzalez-Ericsson P, Stovgaard E, Sua L, Reisenbichler E, Kos Z, Carter J, et al.
J Pathol
. 2020 Mar;
250(5):667-684.
PMID: 32129476
Immune checkpoint inhibitor therapies targeting PD-1/PD-L1 are now the standard of care in oncology across several hematologic and solid tumor types, including triple negative breast cancer (TNBC). Patients with metastatic...