Stephen E Johnston
Overview
Explore the profile of Stephen E Johnston including associated specialties, affiliations and a list of published articles.
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Articles
12
Citations
1276
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Recent Articles
1.
Papanastasiou M, Mullahoo J, DeRuff K, Bajrami B, Karageorgos I, Johnston S, et al.
Mol Cell Proteomics
. 2019 Aug;
18(10):2089-2098.
PMID: 31409669
The N-terminal regions (tails) of histone proteins are dynamic elements that protrude from the nucleosome and are involved in many aspects of chromatin organization. Their epigenetic role is well-established, and...
2.
Michalska K, Gale J, Joachimiak G, Chang C, Hatzos-Skintges C, Nocek B, et al.
IUCrJ
. 2019 Jul;
6(Pt 4):649-664.
PMID: 31316809
Tryptophan biosynthesis is one of the most characterized processes in bacteria, in which the enzymes from and serve as model systems. Tryptophan synthase (TrpAB) catalyzes the final two steps of...
3.
Nagiec M, Duvall J, Skepner A, Howe E, Bastien J, Comer E, et al.
Medchemcomm
. 2018 Dec;
9(11):1831-1842.
PMID: 30542533
Increased expression of the Tribbles pseudokinase 1 gene () is associated with lower plasma levels of LDL cholesterol and triglycerides, higher levels of HDL cholesterol and decreased risk of coronary...
4.
Geller L, Barzily-Rokni M, Danino T, Jonas O, Shental N, Nejman D, et al.
Science
. 2017 Sep;
357(6356):1156-1160.
PMID: 28912244
Growing evidence suggests that microbes can influence the efficacy of cancer therapies. By studying colon cancer models, we found that bacteria can metabolize the chemotherapeutic drug gemcitabine (2',2'-difluorodeoxycytidine) into its...
5.
Over B, Matsson P, Tyrchan C, Artursson P, Doak B, Foley M, et al.
Nat Chem Biol
. 2017 Aug;
13(8):922.
PMID: 28853740
No abstract available.
6.
Wellington S, Nag P, Michalska K, Johnston S, Jedrzejczak R, Kaushik V, et al.
Nat Chem Biol
. 2017 Jul;
13(9):943-950.
PMID: 28671682
New antibiotics with novel targets are greatly needed. Bacteria have numerous essential functions, but only a small fraction of such processes-primarily those involved in macromolecular synthesis-are inhibited by current drugs....
7.
Corsello S, Bittker J, Liu Z, Gould J, McCarren P, Hirschman J, et al.
Nat Med
. 2017 Apr;
23(4):405-408.
PMID: 28388612
No abstract available.
8.
Law J, Stark S, Liu K, Liang N, Hussain M, Leiendecker M, et al.
ACS Med Chem Lett
. 2016 Oct;
7(10):944-949.
PMID: 27774134
Evidence suggests that specific mutations of isocitrate dehydrogenases 1 and 2 (IDH1/2) are critical for the initiation and maintenance of certain tumor types and that inhibiting these mutant enzymes with...
9.
Over B, Matsson P, Tyrchan C, Artursson P, Doak B, Foley M, et al.
Nat Chem Biol
. 2016 Oct;
12(12):1065-1074.
PMID: 27748751
Macrocycles are of increasing interest as chemical probes and drugs for intractable targets like protein-protein interactions, but the determinants of their cell permeability and oral absorption are poorly understood. To...
10.
Johnston S, Gill N, Wei Y, Markovich R, Rustum A
J Chromatogr Sci
. 2010 Sep;
48(9):733-41.
PMID: 20875235
A new stability-indicating reversed-phase HPLC (RP-HPLC) method has been developed and validated for simultaneous assay of betamethasone dipropionate (BD) and chlorocresol and also for the estimation of BD related compounds...