Stephen D Thorpe
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Explore the profile of Stephen D Thorpe including associated specialties, affiliations and a list of published articles.
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38
Citations
913
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Recent Articles
1.
ODowling A, Rodriguez B, Gallagher T, Thorpe S
Comput Struct Biotechnol J
. 2024 Nov;
24:661-671.
PMID: 39525667
The influence of biomechanics on cell function has become increasingly defined over recent years. Biomechanical changes are known to affect oncogenesis; however, these effects are not yet fully understood. Atomic...
2.
Geotemporal Fluorophore Biodistribution Mapping of Colorectal Cancer: Micro and Macroscopic Insights
Hardy N, Mulligan N, Dalli J, Epperlein J, Neary P, Robertson W, et al.
Curr Oncol
. 2024 Feb;
31(2):849-861.
PMID: 38392057
Methods: Fifty consenting patients undergoing treatment for suspected/confirmed colorectal neoplasia provided near infrared (NIR) video and imagery of transanally recorded and ex vivo resected rectal lesions following intravenous ICG administration...
3.
Matellan C, Lachowski D, Cortes E, Chiam K, Krstic A, Thorpe S, et al.
Oncogenesis
. 2023 May;
12(1):23.
PMID: 37130839
Pancreatic ductal adenocarcinoma (PDAC) is the most common and lethal form of pancreatic cancer, characterised by stromal remodelling, elevated matrix stiffness and high metastatic rate. Retinoids, compounds derived from vitamin...
4.
Heywood H, Thorpe S, Jeropoulos R, Caton P, Lee D
Front Bioeng Biotechnol
. 2022 Dec;
10:971932.
PMID: 36561039
This study examined the role of sirtuins in the regenerative potential of articular chondrocytes. Sirtuins (SIRT1-7) play a key role in regulating cartilage homeostasis. By inhibiting pro-inflammatory pathways responsible for...
5.
Brookes O, Thorpe S, Rigby Evans O, Keeling M, Lee D
Front Cell Dev Biol
. 2022 Jun;
10:858884.
PMID: 35652102
Pluripotent cells are subject to much interest as a source of differentiated cellular material for research models, regenerative medical therapies and novel applications such as lab-cultured meat. Greater understanding of...
6.
Ibrahim H, Thorpe S, Paukshto M, Zaitseva T, Moritz W, Rodriguez B
SLAS Technol
. 2022 May;
27(4):267-275.
PMID: 35584761
Cell dissemination during tumor development is a characteristic of cancer metastasis. Dissemination from three-dimensional spheroid models on extracellular matrices designed to mimic tissue-specific physiological microenvironments may allow us to better...
7.
MacCurtain B, Quirke N, Thorpe S, Gallagher T
J Clin Med
. 2021 Jul;
10(12).
PMID: 34205335
Pancreatic ductal adenocarcinoma (PDAC) is the most common form of pancreatic cancer and carries a dismal prognosis. Resectable patients are treated predominantly with surgery while borderline resectable patients may receive...
8.
Thompson C, Fu S, Heywood H, Knight M, Thorpe S
Front Bioeng Biotechnol
. 2021 Mar;
9:658873.
PMID: 33681177
[This corrects the article DOI: 10.3389/fbioe.2020.602646.].
9.
Thompson C, Fu S, Knight M, Thorpe S
Front Bioeng Biotechnol
. 2020 Dec;
8:602646.
PMID: 33363131
Organ-on-chip (OOC) systems recapitulate key biological processes and responses exhibited by cells, tissues, and organs . Accordingly, these models of both health and disease hold great promise for improving fundamental...
10.
Lachowski D, Cortes E, Matellan C, Rice A, Lee D, Thorpe S, et al.
Front Cell Dev Biol
. 2020 Nov;
8:592628.
PMID: 33195261
Mechanical forces regulate cell functions through multiple pathways. G protein-coupled estrogen receptor (GPER) is a seven-transmembrane receptor that is ubiquitously expressed across tissues and mediates the acute cellular response to...