Stephen C Lazarus
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Explore the profile of Stephen C Lazarus including associated specialties, affiliations and a list of published articles.
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84
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4683
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Recent Articles
1.
LaFon D, Helgeson E, Lindberg S, Voelker H, Bhatt S, Casaburi R, et al.
JAMA Netw Open
. 2024 May;
7(5):e247535.
PMID: 38771577
Importance: While β-blockers are associated with decreased mortality in cardiovascular disease (CVD), exacerbation-prone patients with chronic obstructive pulmonary disease (COPD) who received metoprolol in the Beta-Blockers for the Prevention of...
2.
Covar R, Lazarus S, Krishnan J, Blake K, Sorkness C, Dyer A, et al.
J Allergy Clin Immunol Pract
. 2023 Dec;
12(4):960-969.e6.
PMID: 38097180
Background: A multicenter clinical trial in patients with mild persistent asthma indicated that response to inhaled corticosteroids (ICS) is limited to those with sputum eosinophilia. However, testing for sputum eosinophilia...
3.
McKleroy W, Shing T, Anderson W, Arjomandi M, Awan H, Barjaktarevic I, et al.
JAMA
. 2023 Aug;
330(5):442-453.
PMID: 37526720
Importance: People who smoked cigarettes may experience respiratory symptoms without spirometric airflow obstruction. These individuals are typically excluded from chronic obstructive pulmonary disease (COPD) trials and lack evidence-based therapies. Objective:...
4.
Mohan A, Lugogo N, Hanania N, Reddel H, Akuthota P, OByrne P, et al.
Am J Respir Crit Care Med
. 2023 Jun;
207(11):e77-e96.
PMID: 37260227
Patients with mild asthma are believed to represent the majority of patients with asthma. Disease-associated risks such as exacerbations, lung function decline, and death have been understudied in this patient...
5.
Han M, Ye W, Wang D, White E, Arjomandi M, Barjaktarevic I, et al.
N Engl J Med
. 2022 Sep;
387(13):1173-1184.
PMID: 36066078
Background: Many persons with a history of smoking tobacco have clinically significant respiratory symptoms despite an absence of airflow obstruction as assessed by spirometry. They are often treated with medications...
6.
Wise R, Holbrook J, Brown R, Criner G, Dransfield M, He J, et al.
Am J Respir Crit Care Med
. 2022 Jun;
206(7):838-845.
PMID: 35649189
There are no pharmacologic agents that modify emphysema progression in patients with chronic obstructive pulmonary disease (COPD). To evaluate the efficacy of losartan, an angiotensin receptor blocker, to reduce emphysema...
7.
Parekh T, Helgeson E, Connett J, Voelker H, Ling S, Lazarus S, et al.
Ann Am Thorac Soc
. 2022 Apr;
19(10):1642-1649.
PMID: 35363600
The BLOCK COPD (β-Blockers for the Prevention of Acute Exacerbations of Chronic Obstructive Pulmonary Disease) study found that metoprolol was associated with a higher risk of severe exacerbation. To determine...
8.
Hernandez Cordero A, Xi Yang C, Li X, Milne S, Chen V, Hollander Z, et al.
Respir Res
. 2021 Dec;
22(1):316.
PMID: 34937547
Background: Chronic obstructive pulmonary disease (COPD) is an age-related condition that has been associated with early telomere attrition; the clinical implications of telomere shortening in COPD are not well known....
9.
Krishnan J, Lazarus S, Blake K, Sorkness C, Covar R, Dyer A, et al.
Ann Am Thorac Soc
. 2021 Nov;
19(3):372-380.
PMID: 34793687
Whether biomarkers can be used to predict response to inhaled corticosteroids (ICS) or long-acting muscarinic antagonists (LAMA) in mild persistent asthma is unclear. In a prespecified exploratory analysis of a...
10.
Ortega V, Daya M, Szefler S, Bleecker E, Chinchilli V, Phipatanakul W, et al.
Lancet Child Adolesc Health
. 2021 Nov;
5(12):862-872.
PMID: 34762840
Background: Pharmacogenetic studies in asthma cohorts, primarily made up of White people of European descent, have identified loci associated with response to inhaled beta agonists and corticosteroids (ICSs). Differences exist...