Stephen C Hendy
Overview
Explore the profile of Stephen C Hendy including associated specialties, affiliations and a list of published articles.
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8
Citations
577
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Recent Articles
1.
Lubik A, Gunter J, Hollier B, Ettinger S, Fazli L, Stylianou N, et al.
Endocr Relat Cancer
. 2013 Jan;
20(2):173-86.
PMID: 23319492
IGF2 is a mitogenic foetal growth factor commonly over-expressed in cancers, including prostate cancer (PC). We recently demonstrated that insulin can activate de novo steroidogenesis in PC cells, a major...
2.
Wang Q, Bailey C, Ng C, Tiffen J, Thoeng A, Minhas V, et al.
Cancer Res
. 2011 Oct;
71(24):7525-36.
PMID: 22007000
L-Type amino acid transporters such as LAT1 and LAT3 mediate the uptake of essential amino acids. Here, we report that prostate cancer cells coordinate the expression of LAT1 and LAT3...
3.
Lubik A, Gunter J, Hendy S, Locke J, Adomat H, Thompson V, et al.
Cancer Res
. 2011 Jul;
71(17):5754-64.
PMID: 21747118
Androgen-dependent pathways regulate maintenance and growth of normal and malignant prostate tissues. Androgen deprivation therapy (ADT) exploits this dependence and is used to treat metastatic prostate cancer; however, regression initially...
4.
Lai J, Lehman M, Dinger M, Hendy S, Mercer T, Seim I, et al.
RNA
. 2010 Apr;
16(6):1156-66.
PMID: 20406994
In humans, more than 30,000 chimeric transcripts originating from 23,686 genes have been identified. The mechanisms and association of chimeric transcripts arising from chromosomal rearrangements with cancer are well established,...
5.
Locke J, Nelson C, Adomat H, Hendy S, Gleave M, Guns E
J Steroid Biochem Mol Biol
. 2009 May;
115(3-5):126-36.
PMID: 19442514
In castration-resistant prostate cancer (CRPC) many androgen-regulated genes become re-expressed and tissue androgen levels increase despite low serum levels. We and others have recently reported that CRPC tumor cells can...
6.
Read J, Cheng H, Hendy S, Nelson C, Rennie P
Methods Mol Biol
. 2009 Jan;
505:97-122.
PMID: 19117141
Defining the precise promoter DNA sequence motifs where nuclear receptors and other transcription factors bind is an essential prerequisite for understanding how these proteins modulate the expression of their specific...
7.
Locke J, Guns E, Lubik A, Adomat H, Hendy S, Wood C, et al.
Cancer Res
. 2008 Aug;
68(15):6407-15.
PMID: 18676866
Although systemic androgen deprivation prolongs life in advanced prostate cancer, remissions are temporary because patients almost uniformly progress to a state of a castration-resistant prostate cancer (CRPC) as indicated by...
8.
Maffey A, Ishibashi T, He C, Wang X, White A, Hendy S, et al.
Mol Cell Endocrinol
. 2007 Feb;
268(1-2):10-9.
PMID: 17316977
The promoter of the murine probasin (PB) gene exhibits strong androgen receptor (AR)-specific and tissue-specific regulation and is considered a promising candidate for gene therapy treatment of advanced prostate cancer....