Stephen B G Abbott
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Explore the profile of Stephen B G Abbott including associated specialties, affiliations and a list of published articles.
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Recent Articles
11.
Coverdell T, Abbott S, Campbell J
Semin Cell Dev Biol
. 2023 Jul;
156:210-218.
PMID: 37507330
The vagus nerve vitally connects the brain and body to coordinate digestive, cardiorespiratory, and immune functions. Its efferent neurons, which project their axons from the brainstem to the viscera, are...
12.
Li K, Gonye E, Stornetta R, Bayliss C, Yi G, Stornetta D, et al.
J Physiol
. 2023 Jun;
601(16):3667-3686.
PMID: 37384821
The interoceptive homeostatic mechanism that controls breathing, blood gases and acid-base balance in response to changes in CO /H is exquisitely sensitive, with convergent roles proposed for chemosensory brainstem neurons...
13.
Souza G, Stornetta D, Shi Y, Lim E, Berry F, Bayliss D, et al.
J Neurosci
. 2023 Jun;
43(30):5501-5520.
PMID: 37290937
Respiratory chemoreceptor activity encoding arterial Pco and Po is a critical determinant of ventilation. Currently, the relative importance of several putative chemoreceptor mechanisms for maintaining eupneic breathing and respiratory homeostasis...
14.
Souza G, Stornetta D, Vitali A, Wildner H, Zeilhofer H, Campbell J, et al.
Am J Physiol Regul Integr Comp Physiol
. 2022 Aug;
323(4):R512-R531.
PMID: 35993562
In mammals, the pontine noradrenergic system influences nearly every aspect of central nervous system function. A subpopulation of pontine noradrenergic neurons, called A5, are thought to be important in the...
15.
Shi Z, Stornetta R, Stornetta D, Abbott S, Brooks V
Neurosci Lett
. 2022 Jul;
785:136773.
PMID: 35809879
The action of leptin in brain to increase sympathetic nerve activity (SNA) and blood pressure depends upon functional Angiotensin II (AngII) type 1a receptors (AT1aR); however, the sites and mechanism...
16.
Coverdell T, Abraham-Fan R, Wu C, Abbott S, Campbell J
Cell Rep
. 2022 Jun;
39(11):110962.
PMID: 35705034
Motor control of the striated esophagus originates in the nucleus ambiguus (nAmb), a vagal motor nucleus that also contains upper airway motor neurons and parasympathetic preganglionic neurons for the heart...
17.
Souza G, Stornetta R, Stornetta D, Guyenet P, Abbott S
Cell Rep
. 2022 Mar;
38(10):110480.
PMID: 35263582
Hemorrhage initially triggers a rise in sympathetic nerve activity (SNA) that maintains blood pressure (BP); however, SNA is suppressed following severe blood loss causing hypotension. We hypothesized that adrenergic C1...
18.
Abbott S, Souza G
J Physiol
. 2021 Mar;
599(10):2559-2571.
PMID: 33759184
Arousal from sleep in response to CO is a life-preserving reflex that enhances ventilatory drive and facilitates behavioural adaptations to restore eupnoeic breathing. Recurrent activation of the CO -arousal reflex...
19.
Tanaka S, Abe C, Abbott S, Zheng S, Yamaoka Y, Lipsey J, et al.
Proc Natl Acad Sci U S A
. 2021 Mar;
118(12).
PMID: 33737395
Acute kidney injury is highly prevalent and associated with high morbidity and mortality, and there are no approved drugs for its prevention and treatment. Vagus nerve stimulation (VNS) alleviates inflammatory...
20.
Li K, Abbott S, Shi Y, Eggan P, Gonye E, Bayliss D
Cell Rep
. 2021 Feb;
34(5):108714.
PMID: 33535052
Brainstem networks that control regular tidal breathing depend on excitatory drive, including from tonically active, CO/H-sensitive neurons of the retrotrapezoid nucleus (RTN). Here, we examine intrinsic ionic mechanisms underlying the...