Stephen A C Wren
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Explore the profile of Stephen A C Wren including associated specialties, affiliations and a list of published articles.
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Articles
15
Citations
87
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0
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Recent Articles
1.
Wylot M, Whittaker D, Wren S, Bothwell J, Hughes L, Griffin J
NMR Biomed
. 2021 Jan;
34(3):e4456.
PMID: 33398876
Apoptosis maintains an equilibrium between cell proliferation and cell death. Many diseases, including cancer, develop because of defects in apoptosis. A known metabolic marker of apoptosis is a notable increase...
2.
Pisa E, Hughes L, Wren S, Booth J, McCabe J, Whittaker D, et al.
Mol Pharm
. 2020 Apr;
17(6):2021-2033.
PMID: 32298130
The formulation of drug/polymer amorphous solid dispersions (ASDs) is one of the most successful strategies for improving the oral bioavailability of poorly soluble active pharmaceutical ingredients (APIs). Hot-melt extrusion (HME)...
3.
Tres F, Treacher K, Booth J, Hughes L, Wren S, Aylott J, et al.
Mol Pharm
. 2016 Feb;
13(3):1166-75.
PMID: 26845251
Because of its weakly acidic nature (pKa of 4.5), indomethacin presents an aqueous solubility that significantly increases when changing from acidic to neutral/alkaline pH (1.5 μg/mL at pH 1.2 and...
4.
Tres F, Coombes S, Phillips A, Hughes L, Wren S, Aylott J, et al.
Molecules
. 2015 Sep;
20(9):16404-18.
PMID: 26378506
We have investigated the dissolution performance of amorphous solid dispersions of poorly water-soluble bicalutamide in a Kollidon VA64 polymeric matrix as a function of the drug loading (5% vs. 30%...
5.
Tres F, Patient J, Williams P, Treacher K, Booth J, Hughes L, et al.
Mol Pharm
. 2015 Apr;
12(5):1512-22.
PMID: 25872658
Real-time in situ Raman mapping has been employed to monitor, during dissolution, the crystallization transitions of amorphous bicalutamide formulated as a molecular dispersion in a copovidone VA64 matrix. The dissolution...
6.
Tres F, Treacher K, Booth J, Hughes L, Wren S, Aylott J, et al.
J Control Release
. 2014 Jun;
188:53-60.
PMID: 24910191
We have employed for the first time Raman spectroscopic imaging along with multi-variate curve resolution (MCR) analysis to investigate in real time and in-situ the dissolution mechanisms that underpin amorphous...
7.
Coombes S, Hughes L, Phillips A, Wren S
Anal Chem
. 2014 Jan;
86(5):2474-80.
PMID: 24471686
We present the use of (1)H NMR as a new measurement approach for improving understanding of the dissolution of pharmaceutical tablets. NMR has benefits over the conventional UV measurement approach...
8.
Langham Z, Booth J, Hughes L, Reynolds G, Wren S
J Pharm Sci
. 2012 May;
101(8):2798-810.
PMID: 22592919
We have investigated the dissolution mechanisms of spray-dried amorphous solid dispersions of the poorly water-soluble drug felodipine and the water-soluble polymer copovidone using a new combined spectrophotometric and magnetic resonance...
9.
Tate E, Althoefer K, Barras J, Rowe M, Smith J, Pearce G, et al.
Anal Chem
. 2009 Jun;
81(13):5574-6.
PMID: 19492808
Pulsed (35)Cl nuclear quadrupole resonance (NQR) experiments have been performed on 250-mg tablets of the antidiabetic medicine Diabinese to establish the conditions needed for noninvasive quantitative analysis of the medicine...
10.
Lau S, Stainforth N, Watson D, Skellern G, Wren S, Tettey J
Electrophoresis
. 2007 Dec;
29(2):393-400.
PMID: 18080248
CE and hydrogen-deuterium (H/D) exchange MS are useful tools in the analysis and characterisation of peptides. This study reports the facile coupling of these tools in the H/D exchange CE-MS...