Stephanos Pavlides

Overview

Explore the profile of Stephanos Pavlides including associated specialties, affiliations and a list of published articles.

Snapshot

Articles 40

Citations 5031

Followers 0

Related Specialties

Cell Biology

Oncology

Anatomy & Histology

Top 10 Co-Authors

Michael P Lisanti

Federica Sotgia

Ubaldo E Martinez-Outschoorn

Richard G Pestell

Anthony Howell

Diana Whitaker-Menezes

Neal Flomenberg

Philippe G Frank

Aristotelis Tsirigos

Zhao Lin

Published In

Cell Cycle

Cell Tissue Res

Cancer Biol Ther

Proc Natl Acad Sci U S A

Aging (Albany NY)

Affiliations

Soon will be listed here.

Recent Articles

Caveolin-3 Promotes a Vascular Smooth Muscle Contractile Phenotype

Gutierrez-Pajares J, Iturrieta J, Dulam V, Wang Y, Pavlides S, Malacari G, et al.

Front Cardiovasc Med . 2015 Dec; 2:27. PMID: 26664898

Epidemiological studies have demonstrated the importance of cardiovascular diseases in Western countries. Among the cell types associated with a dysfunctional vasculature, smooth muscle (SM) cells are believed to play an...

Caveolin-1 regulates the anti-atherogenic properties of macrophages

Pavlides S, Gutierrez-Pajares J, Katiyar S, Jasmin J, Mercier I, Walters R, et al.

Cell Tissue Res . 2014 Oct; 358(3):821-31. PMID: 25322709

Atherosclerosis is a complex disease initiated by the vascular accumulation of lipoproteins in the sub-endothelial space, followed by the infiltration of monocytes into the arterial intima. Caveolin-1 (Cav-1) plays an...

JNK1 stress signaling is hyper-activated in high breast density and the tumor stroma: connecting fibrosis, inflammation, and stemness for cancer prevention

Lisanti M, Tsirigos A, Pavlides S, Reeves K, Peiris-Pages M, Chadwick A, et al.

Cell Cycle . 2014 Jan; 13(4):580-99. PMID: 24434780

Mammography is an important screening modality for the early detection of DCIS and breast cancer lesions. More specifically, high mammographic density is associated with an increased risk of breast cancer....

Endothelial caveolin-1 plays a major role in the development of atherosclerosis

Pavlides S, Gutierrez-Pajares J, Iturrieta J, Lisanti M, Frank P

Cell Tissue Res . 2014 Jan; 356(1):147-57. PMID: 24390341

Clinical studies have established the important impact of atherosclerotic disease in Western societies. This disease is characterized by the accumulation of lipids and the migration of various cell types in...

BRCA1 mutations drive oxidative stress and glycolysis in the tumor microenvironment: implications for breast cancer prevention with antioxidant therapies

Martinez-Outschoorn U, Balliet R, Lin Z, Whitaker-Menezes D, Birbe R, Bombonati A, et al.

Cell Cycle . 2012 Nov; 11(23):4402-13. PMID: 23172369

Mutations in the BRCA1 tumor suppressor gene are commonly found in hereditary breast cancer. Similarly, downregulation of BRCA1 protein expression is observed in the majority of basal-like breast cancers. Here,...

Atherosclerosis, caveolae and caveolin-1

Pavlides S, Gutierrez-Pajares J, Danilo C, Lisanti M, Frank P

Adv Exp Med Biol . 2012 Mar; 729:127-44. PMID: 22411318

Atherosclerosis is a disease of the blood vessel characterized by the development of an arterial occlusion containing lipid and cellular deposits. Caveolae are 50-100 nm cell surface plasma membrane invaginations...

Is cancer a metabolic rebellion against host aging? In the quest for immortality, tumor cells try to save themselves by boosting mitochondrial metabolism

Ertel A, Tsirigos A, Whitaker-Menezes D, Birbe R, Pavlides S, Martinez-Outschoorn U, et al.

Cell Cycle . 2012 Jan; 11(2):253-63. PMID: 22234241

Aging drives large systemic reductions in oxidative mitochondrial function, shifting the entire body metabolically towards aerobic glycolysis, a.k.a, the Warburg effect. Aging is also one of the most significant risk...

Hyperactivation of oxidative mitochondrial metabolism in epithelial cancer cells in situ: visualizing the therapeutic effects of metformin in tumor tissue

Whitaker-Menezes D, Martinez-Outschoorn U, Flomenberg N, Birbe R, Witkiewicz A, Howell A, et al.

Cell Cycle . 2011 Dec; 10(23):4047-64. PMID: 22134189

We have recently proposed a new mechanism for explaining energy transfer in cancer metabolism. In this scenario, cancer cells behave as metabolic parasites, by extracting nutrients from normal host cells,...

Caveolin-1 and cancer metabolism in the tumor microenvironment: markers, models, and mechanisms

Sotgia F, Martinez-Outschoorn U, Howell A, Pestell R, Pavlides S, Lisanti M

Annu Rev Pathol . 2011 Nov; 7:423-67. PMID: 22077552

Caveolins are a family of membrane-bound scaffolding proteins that compartmentalize and negatively regulate signal transduction. Recent studies have implicated a loss of caveolin-1 (Cav-1) expression in the pathogenesis of human...

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Anti-estrogen resistance in breast cancer is induced by the tumor microenvironment and can be overcome by inhibiting mitochondrial function in epithelial cancer cells

Martinez-Outschoorn U, Goldberg A, Lin Z, Ko Y, Flomenberg N, Wang C, et al.

Cancer Biol Ther . 2011 Nov; 12(10):924-38. PMID: 22041887

Here, we show that tamoxifen resistance is induced by cancer-associated fibroblasts (CAFs). Coculture of estrogen receptor positive (ER+) MCF7 cells with fibroblasts induces tamoxifen and fulvestrant resistance with 4.4 and...