Stephanie S Lehman
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Explore the profile of Stephanie S Lehman including associated specialties, affiliations and a list of published articles.
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12
Citations
260
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Recent Articles
1.
Su Y, Quagliato S, St Louis B, Abdelaziz M, He Y, Bondage D, et al.
Proc Natl Acad Sci U S A
. 2025 Jan;
122(5):e2418613122.
PMID: 39883842
The mammalian Hippo kinases, MST1 and MST2, regulate organ development and suppress tumor formation by balancing cell proliferation and death. In macrophages, inflammasomes detect molecular patterns from invading pathogens or...
2.
Lehman S, Williamson C, Tucholski T, Ellis N, Bouchard S, Jarnik M, et al.
Cell Rep
. 2024 Apr;
43(4):114033.
PMID: 38568811
Small GTPases of the Ras subfamily are best known for their role as proto-oncoproteins, while their function during microbial infection has remained elusive. Here, we show that Legionella pneumophila hijacks...
3.
Lehman S, Verhoeve V, Driscoll T, Beckmann J, Gillespie J
mBio
. 2024 Apr;
15(5):e0075923.
PMID: 38564675
Recent metagenome-assembled genome (MAG) analyses have profoundly impacted Rickettsiology systematics. The discovery of basal lineages (novel families Mitibacteraceae and Athabascaceae) with predicted extracellular lifestyles exposed an evolutionary timepoint for the...
4.
Verhoeve V, Lehman S, Driscoll T, Beckmann J, Gillespie J
bioRxiv
. 2023 Mar;
PMID: 36909625
Recent metagenome assembled genome (MAG) analyses have profoundly impacted Rickettsiology systematics. Discovery of basal lineages (Mitibacteraceae and Athabascaceae) with predicted extracellular lifestyles reveals an evolutionary timepoint for the transition to...
5.
Voss O, Gillespie J, Lehman S, Rennoll S, Beier-Sexton M, Rahman M, et al.
mBio
. 2020 Jun;
11(3).
PMID: 32546622
To establish a habitable intracellular niche, various pathogenic bacteria secrete effectors that target intracellular trafficking and modulate phosphoinositide (PI) metabolism. Murine typhus, caused by the obligate intracellular bacterium , remains...
6.
Lehman S, Noriea N, Aistleitner K, Clark T, Dooley C, Nair V, et al.
mBio
. 2018 Jun;
9(3).
PMID: 29946049
Strains of , the tick-borne agent of Rocky Mountain spotted fever, vary considerably in virulence. Genomic comparisons of strains have identified a relatively small number of genes divergent in an...
7.
Rennoll S, Rennoll-Bankert K, Guillotte M, Lehman S, Driscoll T, Beier-Sexton M, et al.
Infect Immun
. 2017 Nov;
86(1).
PMID: 29084898
species are obligate intracellular bacteria with both conserved and lineage-specific strategies for invading and surviving within eukaryotic cells. One variable component of biology involves arthropod vectors: for instance, typhus group...
8.
Driscoll T, Verhoeve V, Guillotte M, Lehman S, Rennoll S, Beier-Sexton M, et al.
mBio
. 2017 Sep;
8(5).
PMID: 28951473
Reductive genome evolution has purged many metabolic pathways from obligate intracellular (; ). While some aspects of host-dependent rickettsial metabolism have been characterized, the array of host-acquired metabolites and their...
9.
Rennoll-Bankert K, Rahman M, Guillotte M, Lehman S, Beier-Sexton M, Gillespie J, et al.
Infect Immun
. 2016 Oct;
84(12):3496-3506.
PMID: 27698019
Rickettsiae are obligate intracellular pathogens that induce their uptake into nonphagocytic cells; however, the events instigating this process are incompletely understood. Importantly, diverse Rickettsia species are predicted to utilize divergent...
10.
Lehman S, Mladinich K, Boonyakanog A, Mima T, Karkhoff-Schweizer R, Schweizer H
J Microbiol Methods
. 2016 Jul;
129:8-13.
PMID: 27457407
An obstacle for the development of genetic systems for many bacteria is the limited number of antibiotic selection markers, especially for bacteria that are intrinsically antibiotic resistant or where utilization...