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Stephanie E Sellers

Explore the profile of Stephanie E Sellers including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 8
Citations 112
Followers 0
Related Specialties
Hematology
Cell Biology
Reproductive Medicine
Top 10 Co-Authors
Cynthia E Dunbar
Robert E Donahue
John F Tisdale
Mark E Metzger
Neal S Young
Allen E Krouse
Peiman Hematti
Colin O Wu
Thomas Winkler
Bogdan Dumitriu
Published In
Blood
Stem Cells
Mol Ther
Exp Hematol
Mol Ther Nucleic Acids
Affiliations
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Recent Articles
1.
Eltrombopag for patients with moderate aplastic anemia or uni-lineage cytopenias
Fan X, Desmond R, Winkler T, Young D, Dumitriu B, Townsley D, et al.
Blood Adv . 2020 Apr; 4(8):1700-1710. PMID: 32330244
There is no standard or widely effective treatment of patients with moderate aplastic anemia (MAA) or hypo-productive uni-lineage cytopenias (UC). Eltrombopag (EPAG), a small molecule thrombopoietin mimetic, has previously been...
2.
Acquired somatic mutations in PNH reveal long-term maintenance of adaptive NK cells independent of HSPCs
F Corat M, Schlums H, Wu C, Theorell J, Espinoza D, Sellers S, et al.
Blood . 2016 Dec; 129(14):1940-1946. PMID: 27903532
Natural killer (NK) cells have long been considered short-lived effectors of innate immunity. However, recent animal models and human studies suggest that subsets of NK cells have adaptive features. We...
3.
Regulated apoptosis of genetically modified hematopoietic stem and progenitor cells via an inducible caspase-9 suicide gene in rhesus macaques
Barese C, Felizardo T, Sellers S, Keyvanfar K, Di Stasi A, Metzger M, et al.
Stem Cells . 2014 Oct; 33(1):91-100. PMID: 25330775
The high risk of insertional oncogenesis reported in clinical trials using integrating retroviral vectors to genetically modify hematopoietic stem and progenitor cells (HSPCs) requires the development of safety strategies to...
4.
Integration-specific In Vitro Evaluation of Lentivirally Transduced Rhesus CD34(+) Cells Correlates With In Vivo Vector Copy Number
Uchida N, Evans M, Hsieh M, Bonifacino A, Krouse A, Metzger M, et al.
Mol Ther Nucleic Acids . 2013 Sep; 2:e122. PMID: 24045711
Hematopoietic stem cell (HSC) gene therapy using integrating vectors has a potential leukemogenic risk due to insertional mutagenesis. To reduce this risk, a limitation of ≤2 average vector copy number...
5.
No impact of lentiviral transduction on hematopoietic stem/progenitor cell telomere length or gene expression in the rhesus macaque model
Sellers S, Dumitriu B, Morgan M, Hughes W, Wu C, Raghavarchari N, et al.
Mol Ther . 2013 Jul; 22(1):52-8. PMID: 23863881
The occurrence of clonal perturbations and leukemia in patients transplanted with gamma-retroviral (RV) vector-transduced autologous hematopoietic stem and progenitor cells (HSPCs) has stimulated extensive investigation, demonstrating that proviral insertions may...
6.
No evidence of clonal dominance in primates up to 4 years following transplantation of multidrug resistance 1 retrovirally transduced long-term repopulating cells
Bozorgmehr F, Laufs S, Sellers S, Roeder I, Zeller W, Zeller W, et al.
Stem Cells . 2007 Jul; 25(10):2610-8. PMID: 17615269
Previous murine studies have suggested that retroviral multidrug resistance 1 (MDR1) gene transfer may be associated with a myeloproliferative disorder. Analyses at a clonal level and prolonged long-term follow-up in...
7.
The presence of the carboxy-terminal fragment of fibronectin allows maintenance of non-human primate long-term hematopoietic repopulating cells during extended ex vivo culture and transduction
Sellers S, Tisdale J, Agricola B, Donahue R, Dunbar C
Exp Hematol . 2004 Apr; 32(2):163-70. PMID: 15102477
Objective: Ex vivo expansion of primitive hematopoietic cells remains of interest for gene therapy and transplantation. Previous studies reported loss of repopulating activity following culture of cells for more than...
8.
Retroviral transduction efficiency of G-CSF+SCF-mobilized peripheral blood CD34+ cells is superior to G-CSF or G-CSF+Flt3-L-mobilized cells in nonhuman primates
Hematti P, Sellers S, Agricola B, Metzger M, Donahue R, Dunbar C
Blood . 2002 Nov; 101(6):2199-205. PMID: 12424191
Gene transfer experiments in nonhuman primates have been shown to be predictive of success in human clinical gene therapy trials. In most nonhuman primate studies, hematopoietic stem cells (HSCs) collected...